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The migration and attrition of Strongyloides ratti in naive and sensitized rats

Published online by Cambridge University Press:  05 June 2009

T.D. McHugh ,
T. Jenkins ,
R. Greenwood  and
D.J. McLaren
T.D. McHugh
Affiliation:
School of Biological Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK
T. Jenkins
Affiliation:
School of Biological Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK
R. Greenwood
Affiliation:
School of Biological Sciences, University of Portsmouth, Portsmouth, PO1 2DY, UK
D.J. McLaren
Affiliation:
National Institute of Medical Research, Mill Hill, London, NW7 1AA, UK
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Abstract

Compressed organ autoradiography has been utilized to study the migration of the homogonic strain of Strongyloides ratti from the site of skin penetration to the gut. This transit is characterized by rapid disappearance of parasites from the cutaneous site of infection, followed by vascular dispersal throughout all organs investigated. For the first time, parasite migration in both naive and previously sensitized hosts is compared; the principal stations of migration are the same in the two groups although there is a quantitative difference in accumulation of parasites with time in these stations. Parasite attrition occurs in both groups of animals; however, in naive rats it is not manifest until day 20–25 post challenge, whereas in sensitized rats immune elimination occurs as early as 48 h post challenge.

Type
Research Papers
Information
Journal of Helminthology , Volume 68 , Issue 2 , June 1994 , pp. 143 - 148
Copyright
Copyright © Cambridge University Press 1994

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