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Experimental murine model of neurocysticercosis: first report of cerebellum as a location for Mesocestoides corti tetrathyridia

Published online by Cambridge University Press:  01 August 2018

J. Fabbri  and
M.C. Elissondo Open the ORCID record for M.C. Elissondo [Opens in a new window]
J. Fabbri
Affiliation:
Laboratorio de Zoonosis Parasitarias, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3250, 7600, Mar del Plata, Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
M.C. Elissondo*
Affiliation:
Laboratorio de Zoonosis Parasitarias, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3250, 7600, Mar del Plata, Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
*
Author for correspondence: M.C. Elissondo, Fax.: +54 223 475 3150 E-mail: [email protected]
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Abstract

Neurocysticercosis is a parasitic disease caused by encysted larvae of Taenia solium in the human central nervous system. Cysts mainly affect the cerebral hemispheres, although they can also be found in ventricles, basal cisterns, and subarachnoid spaces, and rarely in the cerebellum. Given the impossibility of studying the disease in human patients, Cardona et al. (1999) developed a mouse model of neurocysticercosis, using Mesocestoides corti, a closely related cestode. This allows us to study the parasite–host relationship and the mechanisms involved in the disease, in order to improve the therapy. In this murine model of neurocysticercosis, the location of tetrathyridia in parenchyma, ventricles and meninges has already been reported. The aim of this work is to report the cerebellum as a new location for M. corti tetrathyridia in the murine model of neurocysticercosis. A murine model that reproduces the human pathology is essential to evaluate the symptomatology and response to drug treatment in experimentally infected mice.

Keywords

CerebellumMesocestoides cortineurocysticercosisTaenia solium
Type
Short Communication
Information
Journal of Helminthology , Volume 93 , Issue 5 , September 2019 , pp. 640 - 642
Copyright
Copyright © Cambridge University Press 2018 

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References

Alvarez, JI et al. (2010) Mesocestoides corti intracranial infection as a murine model for neurocysticercosis. Parasitology 137, 359–372.Google Scholar
Amaral, L et al. (2003) Unusual manifestations of neurocysticercosis in MR imaging. Analysis of 172 cases. Arquivos de Neuro-Psiquiatria 61, 533–541.Google Scholar
Cardona, AE et al. (1999) Development of an animal model for neurocysticercosis: immune response in the central nervous system is characterized by a predominance of γδ T cells. Journal of Immunology 162, 995–1002.Google Scholar
Coyle, CM et al. (2012) Neurocysticercosis: neglected but not forgotten. PLoS Neglected Tropical Diseases 6, 1–3.Google Scholar
Del Brutto, OH (2012) Neurocysticercosis: a review. The Scientific World Journal 159821, 1–8.Google Scholar
Fabiani, S and Bruschi, F (2013) Neurocysticercosis in Europe: still a public health concern not only for imported cases. Acta Tropica 128, 18–26.Google Scholar
Gripper, LB and Welburn, SC (2017) Neurocysticercosis infection and disease: a review. Acta Tropica 166, 218–224.Google Scholar
Kim, JH et al. (2006) Giant neurocysticercosis cyst in the cerebellar hemisphere. Neurologia medico-chirurgica 46, 412–414.Google Scholar
Kim, SW et al. (2010) Racemose cysticercosis in the cerebellar hemisphere. Journal of Korean Neurosurgical Society 48, 59–61.Google Scholar
Markoski, MM et al. (2003) In vitro segmentation induction of Mesocestoides corti (cestoda) tetrathyridia. Journal of Parasitology 89, 27–34.Google Scholar
National Research Council US (2011) Guide for the Care and Use of Laboratory Animals. 8th edn. 220 pp. Washington: National Academies Press (US).Google Scholar
Rocca, U, Rosell, A and Alvarez, C (2005) Surgical options in neurocysticercosis therapy. Neurosurgery Quarterly 15, 5–13.Google Scholar
Sorvillo, F et al. (2011) Public health implications of cysticercosis acquired in the United States. Emerging Infectious Diseases 17, 1–6.Google Scholar
WHO (World Health Organization) (2012) Accelerating Work to Overcome the Global Impact of Neglected Tropical Diseases. A Roadmap for Implementation. 14 pp. Geneva: World Health Organization.Google Scholar
Zhu, L et al. (2003) Successful treatment of isolated cerebellar cysticercosis with albendazole. Chinese Medical Journal 116, 637–638.Google Scholar