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Comparative susceptibility to anthelmintics of Brugia pahangi in jirds infected by different methods

Published online by Cambridge University Press:  05 June 2009

Johari Surin  and
D. A. Denham
Johari Surin
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England, UK
D. A. Denham
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England, UK
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Abstract

It is possible to infect jirds with Brugia pahangi by three methods. Infective larvae (L3) can be injected either intraperitoneally (ip), when adults develop in the peritoneal cavity, or sub-cutaneously (sc), when they develop in the lymphatics or the heart and blood vessels associated with the lungs. Alternatively adult worms which have been grown in the peritoneal cavities of jirds can be implanted into the peritoneal cavities of other jirds. This latter system has been widely used for screening for new filaricides. We have compared the activity of 9 macrofilaricidal compounds against these 3 types of infection. Mebendazole and albendazole were more active against implanted adults than against L3 induced adults in the peritoneal cavity. Oxibendazole, flubendazole, CGP24588A and oxfendazole were equally active against both types of worm. CGP20376, Mel Ga and Mel Ni were more active against adult worms derived from inoculated L3 than implanted worms. When comparing intra-lymphatic and ip adults (both derived from L3 infections and in the same jirds) albendazole and CGP20376 were active at the same levels against both types of infection. Mebendazole, flubendazole, oxfendazole, CGP24588A, Mel Ga and Mel Ni were more active against ip adults than intra-lymphatic adults. No drug was more active against intra-lymphatic adults than against adults.

Keywords

Brugia pahangijirdsfilaricidesscreeningoxibendazoleoxfendazoleCGP24588ACGP20376Mel GaMel Nialbendazolemebendazoleflubendazole
Type
Research Article
Information
Journal of Helminthology , Volume 64 , Issue 3 , September 1990 , pp. 232 - 238
Copyright
Copyright © Cambridge University Press 1990

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References

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