Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-03T01:30:57.630Z Has data issue: false hasContentIssue false

Attempts to infect small laboratory animals with the infective larvae of Onchocerca lienalis

Published online by Cambridge University Press:  05 June 2009

S. Townson
Affiliation:
London School of Hygiene ami Tropical Medicine, Winches Farm Field Station, 395 Hat field Road, St. A Ibans, Hertfordshire, ALA OXQ. UK
Dawn Owen
Affiliation:
London School of Hygiene ami Tropical Medicine, Winches Farm Field Station, 395 Hat field Road, St. A Ibans, Hertfordshire, ALA OXQ. UK

Extract

All the natural hosts of Onchocerca parasites are large animals (MULLI-R, 1979) andthere is, therefore an urgent need to develop a small animal model for onchoccrciasis,preferably one that employs a strain of inbred host. Rodents have been usedsuccessfully as experimental hosts for the microfilariac of O. guiturosa (sec NELSON et al. 1966), O. cervicalis (see RAbalais, 1974), O. armilluta (see EL Bihari & Hussein, 1975) and O. ijibsoni (see Beveridge et al., 1980) but there have been few publishedattempts to infect these hosts with infective-stage larvae.

Type
Research Note
Copyright
Copyright © Cambridge University Press 1981

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Beveridge, I., Kummerow, E. & Wilkinson, P. (1980) Experimental Infection Of Laboratoryrodents And calves with microfilariae of Onchocerca gihsoni. Tropenmcdizin und Parasitologic. 3, 8286.Google Scholar
Bianco, A. E., Ham, P., Elsinnary, K. & Nelson, G. S. (1980) Large Scale Recovery Of Onchocerca Microfilariae from naturally infected cattle and horses. Transactions of the Royal Society of Tropical Medicine and Hygiene, 74, 109.Google Scholar
Doenhoff, MMusallum, RBain, J. & Mcgregor, A. (1978) Studies On The Host Parasite Relationship in Schistosoma infected mice: the immunological dependence of parasite egg excretion. Immunology, 35, 771.Google ScholarPubMed
Duke, B. O. L. (1962) Experimental Transmission Of Onchocerca Volvulus From Man To A Chimpanzee. Transactions of the Royal Society of Tropical Medicine and Hygiene, 56, 271.Google Scholar
EL Bihari, S. & Hussein, S.H (1975) Location of the microfilariae of Onchocerca armillata. Journal of Parasitology, 61, 656.CrossRefGoogle ScholarPubMed
Muller, R (1979) The Identification Of Onchocerca. In: Problems In The Identification Of Parasites and their Vectors, pp. 175206. 17th Symposium of the British Society of Parasitology (eds. Taylor, A. E. R. and Muller, R.). Black wells. Oxford.Google Scholar
Nelson, G. S.Amin, M. A., Blackie, E. J. & Robson, N. (1966) The Maintenance Of Onchocerca Gutturosa microfilariae in vitro and in vivo. Transactions of the Royal Society of Tropical Medicine and Hygiene, 60, 17.CrossRefGoogle Scholar
Rabalais, F. C. (1974) Studies On Onchocerca Cervieulis Raillict And Henry 1910 Microfilariae In the jird. Meriones unguiculatus. Journal of Helminthology, 48, 125128.CrossRefGoogle ScholarPubMed
Suswillo, R. R., Nelson, G. S.Muller, R, Mtgreevy, P. B., Duke, B. O. L. & Denham, D. A. (1977) Attempts to infect jirds (Meriones unguiculatus) with 'uchereria bancrofti, Onchercerca volvulus. Loa loa loa. and Mansonella ozzardi. Journal of Helmhuhology, 51, 132134.CrossRefGoogle ScholarPubMed