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An evaluation of the efficacy of monensin against Fasciola hepatica in the albino rat

Published online by Cambridge University Press:  05 June 2009

P. J. Skuce ,
I. Fairweather  and
J. W. M. Kenny
P. J. Skuce
Affiliation:
Department of Zoology, The Queen's University of Belfast, Belfast, BT7 INN
I. Fairweather
Affiliation:
Department of Zoology, The Queen's University of Belfast, Belfast, BT7 INN
J. W. M. Kenny
Affiliation:
Division of Parasitology, Veterinary Research Laboratories, Stormont
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Abstract

The in vivo efficacy of monensin against Fasciola hepatica was determined in the albino rat. The results were variable, with monensin generally showing greater activity against juvenile (two-week-old) than adult (12-week-old) fludes. Significant (p<0·005) reductions in worm burdens were obtained only following treatment of adult flukes with 2×10 mg/kg monensin (52·9% efficacy), and of juvenile flukes with 1×10 mg/kg (42·4% efficacy) and 2×10 mg/kg (56·23% efficacy). Monensin administered in the diet (200 ppm) had a negligible effect on juvenile and adult fluke burdens. Prophylactic treatment of rats with monensin (100 ppm) produced a 45·5% efficacy, but this was not statistically significant. At doses of 1×5 mg/kg and 2×2·5 mg/kg, monensin had little effect on egg output by F. hepatica. No clear relationship was established between egg output and worm burden, and so faecal egg counting was not a reliable indicator of fluke burdens in the rat.

Keywords

MonensinratFasciola hepaticaefficacy
Type
Research Papers
Information
Journal of Helminthology , Volume 61 , Issue 1 , March 1987 , pp. 53 - 58
Copyright
Copyright © Cambridge University Press 1987

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