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3,5-Dibromo-2'-chloro-4'-isothiocyanato salicylanilide in the control of Hymenolepis nana in rats—a pilot study

Published online by Cambridge University Press:  18 November 2009

Suman Gupta ,
J. C. Katiyar ,
S. Sharma  and
A. B. Sen
Suman Gupta
Affiliation:
Central Drug Research Institut, Lucknow 226001, India,
J. C. Katiyar
Affiliation:
Central Drug Research Institut, Lucknow 226001, India,
S. Sharma
Affiliation:
Central Drug Research Institut, Lucknow 226001, India,
A. B. Sen
Affiliation:
Central Drug Research Institut, Lucknow 226001, India,
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Abstract

The efficiency of a new anticestode compound, 3,5-dibromo-2'-chloro-4'-isothiocyanato salicylanilide (GUPTA et al. 1980) for mass eradication of hymenolepiasis from rat colonies was assessed in a pilot study. The drug was administered with milk or food. For effective eradication, depending on the size of animals, single or multiple doses of 100 to 500 mg of the drug'kg body-weight, mixed in milk, or 50mg/kg in feed were necessary. Better results were obtained when the compound was given in feed as it ensured effective consumption irrespective of the seasonal variations. The efficacy of the compound was also assessed on cysticcrcoids in intermediate hosts (Tribalium confusum) by feeding them on flour medicated at 5%, l% and 0.1% levels. None of the concentrations killed the larvae or arrested their development.

Type
Research Article
Information
Journal of Helminthology , Volume 58 , Issue 1 , March 1984 , pp. 7 - 11
Copyright
Copyright © Cambridge University Press 1984

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References

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