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Nutrient and hormone composition of milk is altered in rodent dams post-bariatric surgery

Published online by Cambridge University Press:  09 August 2019

Evangeline M. Deer ,
Bradley Welch ,
Laura L. Hernandez ,
Randy J. Seeley  and
Bernadette E. Grayson Open the ORCID record for Bernadette E. Grayson [Opens in a new window]
Evangeline M. Deer
Affiliation:
Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, USA
Bradley Welch
Affiliation:
Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, USA
Laura L. Hernandez
Affiliation:
Department of Dairy Science, University of Wisconsin-Madison, Madison, WI, USA
Randy J. Seeley
Affiliation:
Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Bernadette E. Grayson*
Affiliation:
Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, USA
*
Address for correspondence: Bernadette E. Grayson, Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA. Email: [email protected]; Phone: 601-984-6809; Fax: 601-984-1655
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Abstract

Although bariatric surgery is approved for a woman of child-bearing age with an interest in subsequent pregnancy, reports of in utero growth issues during pregnancy have garnered a closer look at the impact of maternal surgical weight loss on the pre- and postpartum periods. Offspring of dams having received vertical sleeve gastrectomy (VSG) are born small-for-gestational age and have increased risk for metabolic syndrome later in life. Here, we aimed to determine whether the postnatal catch-up growth trajectory of bariatric offspring may be affected by milk composition. Milk samples were collected at postnatal day 15/16 from dams having received VSG surgery and fed a high-fat diet (HFD) (H-VSG), Sham surgery and fed chow (C-Sham), or Sham surgery and fed HFD (H-Sham). Milk obtained from H-VSG dams had elevated glucose (P < 0.05) and significantly reduced triglyceride content (P < 0.01). Milk from H-Sham dams had the lowest amount of milk protein (P < 0.05). Fatty acid composition measured by fractionation was largely not affected by surgery but rather maternal diet. No difference was observed in milk leptin levels; however, insulin, adiponectin, and growth hormone levels were significantly increased in milk from H-VSG animals. H-Sham had the lowest level of immunoglobulin (Ig)A, whereas IgG was significantly reduced in H-VSG. Taken together, the quality of milk from H-VSG dams suggests that milk composition could be a factor in reducing the rate of growth during the lactation period.

Keywords

Bariatric surgerymilkobesityhormonesnutrients
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 1 , February 2020 , pp. 71 - 77
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019 

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