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Perinatal maternal undernutrition does not result in offspring capillary rarefaction in the middle-aged male baboon at rest

Published online by Cambridge University Press:  19 June 2020

Anderson H. Kuo Open the ORCID record for Anderson H. Kuo [Opens in a new window] ,
Cun Li ,
Hillary F. Huber Open the ORCID record for Hillary F. Huber [Opens in a new window] ,
Peter W. Nathanielsz  and
Geoffrey D. Clarke
Anderson H. Kuo
Affiliation:
Department of Radiology and Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
Cun Li
Affiliation:
Department of Animal Science, University of Wyoming, Laramie, WY, USA Southwest National Primate Research Center, San Antonio, TX, USA
Hillary F. Huber
Affiliation:
Department of Animal Science, University of Wyoming, Laramie, WY, USA
Peter W. Nathanielsz
Affiliation:
Department of Animal Science, University of Wyoming, Laramie, WY, USA Southwest National Primate Research Center, San Antonio, TX, USA
Geoffrey D. Clarke*
Affiliation:
Department of Radiology and Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA Southwest National Primate Research Center, San Antonio, TX, USA
*
Address for correspondence: Geoffrey D. Clarke, Department of Radiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7800, San Antonio, TX78229-3900, USA. Email: [email protected]
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Abstract

Microvascular health is a main determinant of coronary blood flow reserve and myocardial vascular resistance. Extracardiac capillary abnormality has been reported in subjects at increased coronary heart disease risk, such as prehypertension, hypertension, diabetes, hyperlipidemia, and atherosclerosis. We have reported cardiovascular dysfunction in a cohort of maternal nutrient reduction (MNR)-induced intrauterine growth restriction (IUGR) baboon offspring. Here we test the hypothesis that there is oral capillary rarefaction associated with MNR-induced IUGR. Capillary density was quantified using in vivo high-power capillaroscopy on seven middle-aged (~10.7 yr; human equivalent ~40 yr) male IUGR baboons and seven male age-matched controls in the lateral buccal and inferior labial mucosa. While no difference was found between groups in either area by fraction area or optical density for these vascular beds derived from fetal preductal vessels, further studies are needed on post-ductal vascular beds, retina, and function.

Keywords

Maternal nutrient reductionintrauterine growth restriction (IUGR)developmental programmingcapillary densitybaboons
Type
Brief Reports
Information
Journal of Developmental Origins of Health and Disease , Volume 12 , Issue 3 , June 2021 , pp. 349 - 353
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2020

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