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Vascularisation in adipose depots surrounding immune-stimulated lymph nodes

Published online by Cambridge University Press:  01 January 1999

HILARY A. MACQUEEN ,
VERINA WAIGHTS  and
CAROLINE M. POND
HILARY A. MACQUEEN
Affiliation:
Department of Biology, The Open University, Milton Keynes, UK
VERINA WAIGHTS
Affiliation:
Department of Biology, The Open University, Milton Keynes, UK
CAROLINE M. POND
Affiliation:
Department of Biology, The Open University, Milton Keynes, UK
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Abstract

We report a change in the vascularisation of the adipose depots surrounding the popliteal lymph node that has, and the contralateral node that has not, been exposed to a simulated immune challenge. The percentage of the depot that consists of vessels, as measured by image analysis, decreases over a period of 2 d after immune stimulus, then increases in a biphasic manner over the next 2–3 wk. By 1 mo after the stimulus, the vascularisation has returned to baseline values. The adipose tissue surrounding both the stimulated and the unstimulated lymph nodes shows a similar pattern, but the unstimulated depot lags by 3–6 d in reaching its maximum vascularisation. These data support the hypothesis that perinodal adipose tissue is involved in peripheral immune responses.

Keywords

Lymphatic tissueimmune activationperinodal adipose tissue
Type
Research Article
Information
The Journal of Anatomy , Volume 194 , Issue 1 , January 1999 , pp. 33 - 38
Copyright
© Anatomical Society of Great Britain and Ireland 1999

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