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Embryonic Schwann cell development: the biology of Schwann cell precursors and early Schwann cells

Published online by Cambridge University Press:  01 November 1997

K. R. JESSEN  and
R. MIRSKY
K. R. JESSEN
Affiliation:
Department of Anatomy and Developmental Biology, University College London, UK
R. MIRSKY
Affiliation:
Department of Anatomy and Developmental Biology, University College London, UK
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Abstract

The cellular events leading to the generation of Schwann cells from the neural crest have recently been clarified and it is now possible to outline a relatively simple model of the Schwann cell lineage in the rat and mouse. Neural crest cells have to undergo 3 main developmental transitions to become mature Schwann cells. These are the formation of Schwann cell precursors from crest cells, the formation of immature Schwann cells from precursors and, lastly, the postnatal and reversible generation of non-myelin- and myelin-forming Schwann cells. Axonal signals involving neuregulins are important regulators of these events, in particular of the survival, proliferation and differentiation of Schwann cell precursors.

Keywords

Neural crestneuregulinmyelination
Type
Review
Information
The Journal of Anatomy , Volume 191 , Issue 4 , November 1997 , pp. 501 - 505
Copyright
© Anatomical Society of Great Britain and Ireland 1997

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