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Axon guidance of outgrowing corticospinal fibres in the rat

Published online by Cambridge University Press:  01 January 1999

ELBERT A. J. JOOSTEN  and
DOP P. R. BÄR
ELBERT A. J. JOOSTEN
Affiliation:
Department of Neurology, Laboratory of Experimental Neurology, Academic Hospital Utrecht, The Netherlands
DOP P. R. BÄR
Affiliation:
Department of Neurology, Laboratory of Experimental Neurology, Academic Hospital Utrecht, The Netherlands
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Abstract

This review is concerned with the development of the rat corticospinal tract (CST). The CST is a long descending central pathway, restricted to mammals, which is involved both in motor and sensory control. The rat CST is a very useful model in experimental research on the development of fibre systems in mammals because of its postnatal outgrowth throughout the spinal cord as well as its experimental accessibility. Hence mechanisms underlying axon outgrowth and subsequent target cell finding can be studied relatively easily. In this respect the corticospinal tract forms an important example and model system for the better understanding of central nervous system development in general.

Keywords

Corticospinal tractaxon guidancespinal cordadhesion moleculesastrogliadendritesneurotropic
Type
Review
Information
The Journal of Anatomy , Volume 194 , Issue 1 , January 1999 , pp. 15 - 32
Copyright
© Anatomical Society of Great Britain and Ireland 1999

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