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Hair bundle profiles along the chick basilar papilla

Published online by Cambridge University Press:  20 March 2001

R. K. DUNCAN ,
K. E. ILE ,
M. G. DUBIN  and
J. C. SAUNDERS
R. K. DUNCAN
Affiliation:
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
K. E. ILE
Affiliation:
Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA
M. G. DUBIN
Affiliation:
Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, PA, USA
J. C. SAUNDERS
Affiliation:
Department of Otolaryngology, University of North Carolina, Chapel Hill, NC, USA
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Abstract

Cochlear hair cells play a central role in the transduction of sound into neural output. Anatomical descriptions of these cells, and their protruding hair bundles, are of fundamental interest since hair cell transduction is dependent on hair bundle micromechanics and hair bundle micromechanics depends on hair bundle morphology. In this paper, we describe quantitatively changes in the staircase profile of the hair bundle along the apical portion of the chick's basilar papilla. Images of hair cells from 8 discretely dissected segments of the apical 3rd of the basilar papilla were archived, and the profile contour outlined by the tips of the stereocilia was digitised and curves were fitted by linear and power equations. The hair bundles of tall hair cells exhibited both linear and curvilinear profiles, which were equally distributed along the papilla. All short hair cells in our sample had straight contours. The differences in hair bundle shape among the tall hair cells may lead to differential susceptibility to injury and some variance in the current-displacement transduction curves due to differences in the translation of forces throughout the hair bundle.

Keywords

Auditory systemhair cellsstereocilia
Type
Research Article
Information
The Journal of Anatomy , Volume 198 , Issue 1 , January 2001 , pp. 103 - 116
Copyright
© Anatomical Society of Great Britain and Ireland 2001

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