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Toxicity of lofepramine in heart disease

Published online by Cambridge University Press:  13 June 2014

Bankole A Johnson ,
Jacinta McCann  and
Efunbowale A Johnson
Bankole A Johnson
Affiliation:
Warneford Hospital, Warneford Lane, Headington, Oxford OX3 7JX.
Jacinta McCann
Affiliation:
Warneford Hospital, Warneford Lane, Headington, Oxford OX3 7JX.
Efunbowale A Johnson
Affiliation:
St. Mary's Hospital, Praed Street, London W2.
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Abstract

Lofepramine at the upper limit of its therapeutic range (210mg/day), was associated with the development of sinus tachycardia with atrial ectopic beats and progression of right bundle branch block to trifascicular block in an 82 year old man with a history of heart disease. As with any antidepressant administered in a high therapeutic dose, caution and regular electrocardiographic monitoring of elderly patients with heart disease receiving lofepramine is recommended.

Type
Clinical and Brief Reports
Information
Irish Journal of Psychological Medicine , Volume 7 , Issue 2 , September 1990 , pp. 142 - 143
Copyright
Copyright © Cambridge University Press 1990

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