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Neuroleptic induced polydipsia and hyperphagia in an adult with learning disability

Published online by Cambridge University Press:  13 June 2014

Syed Hasan Jawed
Affiliation:
Cherry Orchard House, 35 Hospital Street, Tamworth, Staffordshire B79 7EE, England

Abstract

This case report is of a young male with learning disability, who presented with long-term polydipsia and hyperphagia. The patient's polydipsia and hyperphagia showed a correlation with long-term use of neuroleptics for behavioural problems. Withdrawal of all neuroleptic medication resulted in an immediate improvement in both the polydipsia and hyperphagia leading to a complete resolution of both symptoms. While neuroleptics are a recognised cause of polydipsia, hyperphagia is less frequently described and we believe this to be the first report in which a patient is observed to have polydipsia and hyperphagia induced by neuroleptics. We discuss the possible aetiological mechanisms for both polydipsia and hyperphagia and conclude that the basic pathophysiology in our case appears to be a neuroleptic induced malfunction of the satiety centre due to blockage of dopamine receptors in the ventromedial hypothalamus.

Type
Case Report
Copyright
Copyright © Cambridge University Press 1998

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