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Vitamin B12 Deficiency and Dementia

Published online by Cambridge University Press:  07 January 2005

Ulisses Gabriel de Vasconcelos Cunha
Affiliation:
Geriatric Unit, Hospital dos Servidores do Estado de Minas Gerais, Belo Horizonte, Brazil
Fábio Lopes Rocha
Affiliation:
Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Josecy Maria de Souza Peixoto
Affiliation:
Geriatric Unit, Hospital dos Servidores do Estado de Minas Gerais, Belo Horizonte, Brazil
Maria Flávia de Morão Motta
Affiliation:
Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Maira Tonidandel Barbosa
Affiliation:
Geriatric Unit, Hospital dos Servidores do Estado de Minas Gerais, Belo Horizonte, Brazil
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Abstract

We set out to investigate the possible beneficial effects on cognitive function of demented patients with cobalamin deficiency after cobalamin replacement. A total of 181 consecutive, demented (DSM-III or DSM-III-R criteria and score below 24 on the Mini-Mental State Examination [MMSE] outpatients (mean age 77.5 years) were prospectively evaluated and had their vitamin B12 level measured by radioimmunoassay. The frequency of vitamin B12 deficiency (less than 200 pg/mL) was 25% (46 patients). Treatment outcome was obtained in 19 patients (19 of 46). Despite cobalamin replacement, 16 of 19 patients persisted in showing progressive decline during follow-up visits (3 to 24 months). The nonresponse to vitamin B12 replacement in most cases seems to reflect the presence of associated irreversible dementia or a follow-up of shorter duration in a few patients. All of the patients who showed some improvement (MMSE returned to normal values) had mild dementia with a history of less than 2 years. Thus, screening for B12 deficiency should be considered in patients with recent onset of mild mental status changes.

Type
Research and Reviews
Copyright
© 1995 Springer Publishing Company

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