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Guidelines for Brain Imaging in Vascular Dementia Clinical Trials

Published online by Cambridge University Press:  10 January 2005

Frederik Barkhof
Frederik Barkhof
Affiliation:
Image Analysis Centre, VU Medical Centre, Amsterdam, The Netherlands
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Abstract

Imaging should be included in the workup of dementia patients and is mandatory for the diagnosis of vascular dementia (VaD). MRI is the preferred imaging modality and should include axial T2 and FLAIR, preferably accompanied by a 3D T1-weighted sequence in clinical trials to determine white-matter lesions, infarcts, lacunes, and atrophy. Gradient echo images are needed for microbleeds. Diagnostic criteria should be operationalized and validated visual rating scales are available. In clinical trials, standardized acquisition protocols and central data analysis are mandatory. More work is needed to determine the natural progression in VaD and the possible use of MRI-based outcome measures.

Keywords

Vascular dementiaclinical trialsMRIoutcome measure
Type
TRIL DESIGNS: ISSUES
Information
International Psychogeriatrics , Volume 15 , Issue S1 , July 2003 , pp. 273 - 276
Copyright
© 2003 International Psychogeriatric Association

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