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Apolipoprotein E and Functional Illness in the Elderly

Published online by Cambridge University Press:  10 January 2005

Clive Holmes
Clive Holmes
Affiliation:
The Maudsley, Institute of Psychiatry, London, England
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Following on from the hypothesis of a role for the ApoE ε4 and ε2 alleles as risk and protective factors, respectively, for late-onset Alzheimer's disease (AD) came inevitable questions regarding other psychiatric conditions of late onset including depressive illness and schizophrenia. Is ApoE ε4 a risk factor in these diseases and do carriers have an earlier age of onset? Does ApoE ε2 have a protective role, with carriers of this allele having a later age of onset?

Type
Guest Editorials
Information
International Psychogeriatrics , Volume 10 , Issue 1 , March 1998 , pp. 3 - 6
Copyright
© 1998 International Psychogeriatric Association