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A review of the effectiveness of memory interventions in mild cognitive impairment (MCI)

Published online by Cambridge University Press:  15 October 2010

Joshua Stott  and
Aimee Spector
Joshua Stott*
Affiliation:
Research Department of Clinical, Educational and Health Psychology, University College London, London, U.K.
Aimee Spector
Affiliation:
Research Department of Clinical, Educational and Health Psychology, University College London, London, U.K.
*
Correspondence should be addressed to: Dr Joshua Stott, Research Department of Clinical, Educational and Health Psychology, University College London, 1–19 Torrington Place, London WC1E 6BR, U.K. Phone: +44 (0)20-7679-1844; Fax: +44 (0)20-7916-1989. Email: [email protected].
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Abstract

Background: Mild cognitive impairment (MCI) is commonly associated with memory impairment. There have been a number of studies attempting to ameliorate this through memory interventions including memory rehabilitation and training. The current paper reviews the evidence for the effectiveness of such interventions in enhancing learning of specific information, their impact on untrained material, compensation for memory impairment and improving everyday functioning.

Methods: The literature was systematically searched for studies focusing on interventions targeting memory impairment in MCI using relevant search terms. Studies were screened for inclusion or exclusion using a priori criteria and, once identified, studies were examined for quality using pre-specified criteria.

Results: A total of 226 studies were identified in the search, ten of which were included in the final review. Only one study was an RCT of “adequate” methodology. It was tentatively suggested that people with MCI can learn specific information, although there was little evidence to suggest that memory training can generalize. There was some limited evidence of ability to learn to compensate for memory difficulties and contradictory findings regarding improvement in everyday life.

Conclusions: The poor methodological quality of the included studies implies that the ability to draw conclusions is limited. MCI is a controversial concept and there is a need for good quality trials examining the efficacy of memory interventions. There are some indications that memory impairment in MCI might best be targeted by interventions developing compensatory strategies and targeting the learning of specific information relevant to the individual.

Keywords

MCIdementiacognitive disordersmemory
Type
Review Article
Information
International Psychogeriatrics , Volume 23 , Issue 4 , May 2011 , pp. 526 - 538
Copyright
Copyright © International Psychogeriatric Association 2010

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References

Akhtar, S., Moulin, C. J. and Bowie, P. C. (2006). Are people with mild cognitive impairment aware of the benefits of errorless learning? Neuropsychological Rehabilitation, 16, 329–346.CrossRefGoogle ScholarPubMed
Belleville, S., Chatelois, J., Fontaine, F., Lussier, I., Peretz, I. and Renaseau-Leclerc, C. (1992). Batterie informatisée d’évaluation de la mémoire. Montréal: Côte-des-Neiges.Google Scholar
Belleville, S., Gilbert, B., Fontaine, F., Gagnon, L., Menard, E. and Gauthier, S. (2006). Improvement of episodic memory in persons with mild cognitive impairment and healthy older adults: evidence from a cognitive intervention program. Dementia and Geriatric Cognitive Disorders, 22, 486–499.CrossRefGoogle ScholarPubMed
Belleville, S. (2008). Cognitive training for persons with mild cognitive impairment. International Psychogeriatrics, 20, 57–66.CrossRefGoogle ScholarPubMed
Bolla, K. I., Lindgren, K. N., Bonaccorsy, K. and Bleecker, M. (1991). Memory complaints in older adults: fact or fiction? Archives of Neurology, 48, 61–64.CrossRefGoogle ScholarPubMed
Bravo, G., Goulin, P. and Dubois, M-F. (1996). Validation d'une échelle de bien-être général auprès d'une population âgées de 50 à 75 ans.Canadian Journal of Aging, 151, 112–128.CrossRefGoogle Scholar
Busse, A., Bischkopf, J., Riedel-Heller, S. G. and Angermeyer, M. C. (2003). Subclassifications for mild cognitive impairment: prevalence and predictive validity. Psychological Medicine, 33, 1029–38.CrossRefGoogle ScholarPubMed
Chertkow, H. et al. (2007). Mild cognitive impairment and cognitive impairment, no dementia: Part A. Concept and diagnosis. Alzheimer's and Dementia, 3, 266–282.CrossRefGoogle Scholar
Cipriani, G., Bianchetti, A. and Trabucchi, M. (2006). Outcomes of a computer-based cognitive rehabilitation program on Alzheimer's disease patients compared with those on patients affected by mild cognitive impairment. Archives of Gerontology and Geriatrics, 43, 327–335.CrossRefGoogle ScholarPubMed
Clare, L., Wilson, B. A., Carter, G., Breen, K., Gosses, A. and Hodges, J. R. (2000). Intervening with everyday memory problems in dementia of Alzheimer type: an errorless learning approach. Journal of Clinical and Experimental Neuropsychology, 22, 132–146.CrossRefGoogle ScholarPubMed
Clare, L., Woods, R. T., Moniz-Cook, E. D., Orrell, M. and Spector, A. (2003). Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia (review). Cochrane Database Systematic Review, 4, CD003260.Google Scholar
Farias, S., Mungas, D., Reed, B., Harvey, D., Cahn-Weiner, D. and DeCarli, C. (2006). MCI is associated with deficits in everyday functioning. Alzheimer Disease and Associated Disorders, 20, 217–223CrossRefGoogle ScholarPubMed
Farinal, E. et al. (2002). Comparing two programs of cognitive training in Alzheimer's disease: a pilot study. Acta Neurologia Scandinavica, 105, 365–371CrossRefGoogle Scholar
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1974). “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198CrossRefGoogle Scholar
Gély-Nargeot, M. C., Cadilhac, C., Touchon, J. and Nespoulous, J. L. (1997). La mémoire de textes chez les sujets sains et déments: application d'un nouvel outil d’évaluation pour neuro psychologues: mémo-textes. In Lambert, J. and Nespoulous, J. L. (eds.), Perception auditive et compréhension du langage. (pp. 273–293). Marseille: Solal.Google Scholar
Greenaway, M. C., Hanna, S. M., Lepore, S. W. and Smith, G. E. (2008). A behavioral rehabilitation intervention for amnestic mild cognitive impairment. American Journal of Alzheimer's Disease and Other Dementias, 23, 451–461CrossRefGoogle ScholarPubMed
Grundman, M., Petersen, R. C. and Morris, J. C. (1996). ADSC Cooperative Study: rate of dementia of the Alzheimer type (DAT) in subjects with mild cognitive impairment. Neurology, 46, A403.Google Scholar
Hampstead, B. M., Sathian, K., Moore, A. B., Nalisnick, C. and Stringer, A. Y. (2008). Explicit memory training leads to improved memory for face-name pairs in patients with mild cognitive impairment: results of a pilot investigation. Journal of the International Neuropsychological Society, 14, 883–889.CrossRefGoogle ScholarPubMed
Jadad, A. R. et al. (1996). Assessing the quality of reports of randomized clinical trials: is blinding necessary? Controlled Clinical Trials, 17, 1–12.CrossRefGoogle ScholarPubMed
Jean, L., Bergeron, M., Thivierge, S. B. A. and Simard, M. (2010). Cognitive intervention programs for individuals with mild cognitive impairment: systematic review of the literature. American Journal of Geriatric Psychiatry, 18, 281–296CrossRefGoogle ScholarPubMed
Klepstad, P. (2002). Self-reports are not related to objective assessments of cognitive function and sedation in patients with cancer pain admitted to a palliative care unit. Palliative Medicine, 16, 513–519.CrossRefGoogle Scholar
Lachman, M. E., Bandura, M., Weaver, S. L. and Elliot, E. (1995). Assessing memory control beliefs: the memory controllability inventory. Aging and Cognition, 2, 67–84.Google Scholar
Lawton, M. P. and Brody, E. M. (1969). Assessment of older people: self maintaining and instrumental activities of daily living. Gerontologist, 9, 179–186.CrossRefGoogle ScholarPubMed
Logsdon, R., Gibbons, L., McCurry, S. and Teri, L. (1999). Quality of life in Alzheimer's disease: patient and caregiver reports. Journal of Mental Health and Ageing, 5, 21–32.Google Scholar
Londos, E., Boschian, K., Linden, A., Persson, C., Minthon, L. and Lexell, J. (2008). Effects of a goal-oriented rehabilitation program in mild cognitive impairment: a pilot study. American Journal of Alzheimer's Disease and Other Dementias, 23, 177–183.CrossRefGoogle ScholarPubMed
Lopez, O., Jagust, W., DeKosky, S. and Becker, D. (2002). Risk factors for mild cognitive impairment in a population study. Neurology, 58, A238.Google Scholar
Massoud, F. et al. (2007). Mild cognitive impairment and cognitive impairment, no dementia. Part B: Therapy. Alzheimer's Disease and Dementia, 3, 283–291.CrossRefGoogle ScholarPubMed
Mazzoni, G. and Nelson, T. O. (1995). Judgements of learning are affected by the kind of encoding in ways that cannot be attributed to the level of recall.Journal of ExperimentalPsychology: Learning, Memory, and Cognition, 21, 1263–1274.Google Scholar
Novelli, G. et al. (1986). Tre test clinici di memoria verbale a lungo termine. Taratura su soggetti normali. Archivio di Psicologia, Neurologia e Psichiatria, 47, 278–296.Google Scholar
Olazaran, J. et al. (2004). Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease. Neurology, 63, 2348–2353.CrossRefGoogle ScholarPubMed
Osterreith, P. A. (1944). Le test de copie d'une figure complexe. Archives de Psychologie, 30, 206–256.Google Scholar
Owen, A. M. et al. (2010). Putting brain training to the test. Nature, 10, 465, 775–778.CrossRefGoogle Scholar
Petersen, R. C. (2004). Mild cognitive impairment as a diagnostic entity. Journal of Internal Medicine, 256, 183–194.CrossRefGoogle ScholarPubMed
Petersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L., and DeKosky, S. T. (2001). Practice parameter: early detection of dementia. Mild cognitive impairment (an evidence-based review). Neurology, 56, 1133–1142.CrossRefGoogle ScholarPubMed
Pettigrew, M. and Gilbody, S. (2002). Planning and conducting systematic reviews. In Michie, S. and Abraham, C. (eds.), Health Psychology in Practice (pp. 150–79). Oxford: BPS Blackwell.Google Scholar
Rapp, S. R., Brenes, G. and Marsh, A. P. (2002). Memory enhancement training for older adults with mild cognitive impairment: a preliminary study. Aging and Mental Health, 6, 5–11.CrossRefGoogle ScholarPubMed
Ready, E., Ott, B. R. and Grace, J. F. I. (2002). The Cornell-Brown Scale for Quality of Life in Dementia. Alzheimer Disease and Associated Disorders, 16, 109–115.CrossRefGoogle ScholarPubMed
Rozzini, L., Costardi, D., Chilovi, B. V., Franzoni, S., Trabucchi, M. and Padovani, A. (2007). Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors. International Journal of Geriatric Psychiatry, 22, 4, 356–360.CrossRefGoogle ScholarPubMed
Rubin, D. and Friendly, M. (1986). Predicting which words get recalled: measures of free recall, availability, goodness, emotionality, and pronunciability for 925 nouns. Memory and Cognition, 14, 79–94.CrossRefGoogle ScholarPubMed
Scogin, F., Prohaska, M. and Weeks, E. (1998). The comparative efficacy of self-taught and group memory training for older adults. Journal of Clinical Geropsychology, 4, 301–314.Google Scholar
Sheikh, J. and Yesavage, J. (1986). Geriatric Depression Scale (GDS). Clinical Gerontologist, 5, 165–173.Google Scholar
Sitzer, D. I., Twamley, E. W. and Jeste, D. V. (2006). Cognitive training in Alzheimer's disease: a meta-analysis of the literature. Act Psychiatrica Scandinavica, 114, 75–90.CrossRefGoogle ScholarPubMed
Spector, A. et al. (2003). Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial. British Journal of Psychiatry, 183, 248–254.CrossRefGoogle ScholarPubMed
Talassi, E., Guerreschi, M., Feriani, M., Fedi, V., Bianchetti, A. and Trabucchi, M. (2007). Effectiveness of a cognitive rehabilitation program in mild dementia (MD) and mild cognitive impairment (MCI): a case control study. Archives of Gerontology and Geriatrics, 44, 391–399.CrossRefGoogle ScholarPubMed
Troyer, A. K. (2001). Improving memory knowledge, satisfaction, and functioning via an education and intervention program for older adults. Aging, Neuropsychology, and Cognition, 8, 256–268.CrossRefGoogle Scholar
Troyer, A. K. and Rich, J. B. (2002). Psychometric properties of a new metamemory questionnaire for older adults. Journals of Gerontology: Psychological Sciences, 57, 19–27.CrossRefGoogle ScholarPubMed
Troyer, A. K., Murphy, K. J., Anderson, N. D., Moscovitch, M. and Craik, F. I. (2008). Changing everyday memory behaviour in amnestic mild cognitive impairment: a randomised controlled trial. Neuropsychological Rehabilitation, 18, 1, 65–88.CrossRefGoogle ScholarPubMed
Tuokko, H. and Frerichs, R. J. (2000). Cognitive impairment with no dementia (CIND): longitudinal studies, the findings, and the issues. Clinical Neuropsychologist, 14, 504–525.CrossRefGoogle ScholarPubMed
van der Linden, M., Wijns, C. h., von Frenkell, R., Coyette, F. and Seron, X. (1989). Un questionnaire d'auto-évaluation de la mémoire QAM [A Memory Auto-assessment Questionnaire]. Bruxelles: Editest.Google Scholar
Verhaeghen, P., Marcoen, A. and Goossens, L. (1992). Improving memory performance in the aged through mnemonic training: a meta-analytic study. Psychology and Aging, 7, 242–251.CrossRefGoogle ScholarPubMed
Weintraub, S. (1986). Record of Independent Living: an informant-completed measure of ADLs and behavior in elderly patients with cognitive impairment. American Journal of Alzheimer's Care and Related Disorders, 7, 35–39.CrossRefGoogle Scholar
Wechsler, D. (1987). Wechsler Memory Scale, Revised Manual. New York: Psychological Corporation.Google Scholar
Wilson, B. A., Cockburn, J. and Baddeley, A. D. (1985). The Rivermead Behavioural Memory Test Manual. Reading: Thames Valley Test Company.Google Scholar
Wressle, E., Samuelsson, K. and Henriksson, C. (1999). Responsiveness of the Swedish version of the Canadian Occupational Performance Measure. Scandinavian Journal of Occupational Therapy, 6, 84–89.CrossRefGoogle Scholar
York Centre for Systematic Reviews (2001). Undertaking Systematic Reviews of Research on Effectiveness: CRD's Guidance for those Carrying Out or Commissioning Reviews. CRD Report 4 (2nd edition). Available at http://www.york.ac.uk/inst/crd/report4.htm; last accessed 20 June 2009.Google Scholar
Zelinski, E. M., Gilewski, M. J. and Anthony-Bergstone, C. R. (1990). Memory Functioning Questionnaire: concurrent validity with memory performance and self reported memory failures. Psychology and Aging, 5, 388–399.CrossRefGoogle ScholarPubMed