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No lower cognitive functioning in older adults with attention-deficit/hyperactivity disorder

Published online by Cambridge University Press:  06 February 2015

E. J. Semeijn ,
N. C. M. Korten ,
H. C. Comijs ,
M. Michielsen ,
D. J. H. Deeg ,
A. T. F. Beekman  and
J. J. S. Kooij
E. J. Semeijn*
Affiliation:
Department of Psychiatry, The Netherlands EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands Expertise Centre ADHD in Adults, PsyQ, The Hague, the Netherlands
N. C. M. Korten
Affiliation:
Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands
H. C. Comijs
Affiliation:
Department of Psychiatry, The Netherlands EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands
M. Michielsen
Affiliation:
Department of Psychiatry, The Netherlands EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands Expertise Centre ADHD in Adults, PsyQ, The Hague, the Netherlands
D. J. H. Deeg
Affiliation:
Department of Psychiatry, The Netherlands EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands
A. T. F. Beekman
Affiliation:
Department of Psychiatry, The Netherlands EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands
J. J. S. Kooij
Affiliation:
Expertise Centre ADHD in Adults, PsyQ, The Hague, the Netherlands
*
Correspondence should be addressed to: Evert Semeijn, VU University Medical Centre Amsterdam, LASA, Van der Boechorststraat 7, 1081BT Amsterdam, the Netherlands. Phone: +31 20 444 6770; Fax: +31 20 444 6775. Email: [email protected].
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Abstract

Background:

Research illustrates cognitive deficits in children and younger adults with attention-deficit/hyperactivity disorder (ADHD). Few studies have focused on the cognitive functioning in older adults. This study investigates the association between ADHD and cognitive functioning in older adults.

Methods:

Data were collected in a cross-sectional side study of the Longitudinal Aging Study Amsterdam (LASA). A diagnostic interview to diagnose ADHD was administered among a subsample (N = 231, age 60–94). ADHD symptoms and diagnosis were assessed with the Diagnostic Interview for ADHD in Adults (DIVA) 2.0. Cognitive functioning was assessed with tests in the domains of executive functioning, information processing speed, memory, and attention/working memory.

Results:

Regression analyses indicate that ADHD diagnosis and ADHD severity were only negatively associated with cognitive functioning in the attention/working memory domain. When adjusting for depression, these associations were no longer significant.

Conclusion:

The study shows that ADHD in older adults is associated with lower cognitive functioning in the attention/working memory domain. However, this was partly explained by depressive symptoms.

Keywords

attention-deficit/hyperactivity disorderADHDcognitive functioningcognition
Type
Research Article
Information
International Psychogeriatrics , Volume 27 , Issue 9 , September 2015 , pp. 1467 - 1476
Copyright
Copyright © International Psychogeriatric Association 2015 

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References

Alexopoulos, G. S. (2005). Depression in the elderly. Lancet, 365, 1961–1970. doi:10.1016/S0140-6736(05)66665-2.CrossRefGoogle ScholarPubMed
American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders (IV-TR.). Washington, DC: American Psychiatric Association.Google Scholar
Barkley, R. A., Fischer, M., Smallish, L. and Fletcher, K. (2002). The persistence of attention-deficit/hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder. Journal of Abnormal Psychology, 111, 279–289.Google Scholar
Barkley, R. A., Murphy, K. R. and Fischer, M. (2010). ADHD in Adults. What the Science Says. New York: The Guilford Press.Google Scholar
Bunce, D., Batterham, P. J., Mackinnon, A. J. and Christensen, H. (2012). Depression, anxiety and cognition in community-dwelling adults aged 70 years and over. Journal of Psychiatric Research, 46, 1662–1666. doi:10.1016/j.jpsychires.2012.08.023.Google Scholar
Butters, M. A. et al. (2008). Pathways linking late-life depression to persistent cognitive impairment and dementia. Dialogues in Clinical Neuroscience, 10, 345–357.Google Scholar
Central Bureau of Statistics (1989). Health Interview Questionnaire. The Hague.Google Scholar
Curry, J., March, J. and Hervey, A. (2004). Comorbidity of childhood and adolescent anxiety disorders: prevalence and implications. In Ollendick, T. and March, J. (eds.), Phobic and Anxiety Disorders in Children and Adolescents: A Clinician's Guide to Effective Psychosocial and Pharmacological Interventions (pp. 116–140). New York: Oxford University Press.CrossRefGoogle Scholar
Das, D., Cherbuin, N., Easteal, S. and Anstey, K. J. (2014). Attention deficit/hyperactivity disorder symptoms and cognitive abilities in the late-life cohort of the PATH through life study. PLoS ONE, e86552. doi:10.1371/journal.pone.0086552.Google Scholar
Dixon, R., Bäckman, L. and Nillsson, L.-G. (2004). New Frontiers in Cognitive Aging. The Lancet Neurology. Oxford: Oxford University Press.CrossRefGoogle Scholar
Elderkinthompson, V., Mintz, J., Haroon, E., Lavretsky, H. and Kumar, A. (2007). Executive dysfunction and memory in older patients with major and minor depression. Archives of Clinical Neuropsychology, 22, 261–270. doi:10.1016/j.acn.2007.01.021.Google Scholar
Field, A. (2011). Discovering Statistics Using SPSS, 3rd edn. London: SAGE Publications Ltd.Google Scholar
Folstein, M. F., Folstein, S. E. and McHugh, P. R. (1975). Mini-mental state: a practical method for the clinician. Journal of Psychiatric Research, 12, 189–198. doi:10.1016/0022-3956(75)90026-6.CrossRefGoogle Scholar
Golimstok, A., Rojas, J. I., Romano, M., Zurru, M. C., Doctorovich, D. and Cristiano, E. (2011). Previous adult attention-deficit and hyperactivity disorder symptoms and risk of dementia with Lewy bodies: a case-control study. European Journal of Neurology, 18, 78–84. doi:10.1111/j.1468-1331.2010.03064.x.Google Scholar
Harvey, R., Skelton-Robinson, M. and Rossor, M. (2003). The prevalence and causes of dementia in people under the age of 65 years. Journal of neurology, neurosurgery, and psychiatry, 74, 1206–1209.CrossRefGoogle ScholarPubMed
Hervey, A. S., Epstein, J. N. and Curry, J. F. (2004). Neuropsychology of adults with attention-deficit/hyperactivity disorder: a meta-analytic review. Neuropsychology, 18, 485–503. doi:10.1037/0894-4105.18.3.485.CrossRefGoogle ScholarPubMed
Huisman, M. et al. (2011). Cohort profile: the Longitudinal Aging Study Amsterdam. International Journal of Epidemiology, 40, 868–876. doi:10.1093/ije/dyq219.CrossRefGoogle ScholarPubMed
Ivanchak, N., Fletcher, K. and Jicha, G. A. (2012). Attention-deficit/hyperactivity disorder in older adults: prevalence and possible connections to mild cognitive impairment. Current Psychiatry Reports, 14, 552–560. doi:10.1007/s11920-012-0305-8.CrossRefGoogle ScholarPubMed
Ivanchak, N. et al. (2011). Attention-deficit/hyperactivity disorder in childhood is associated with cognitive test profiles in the geriatric population but not with mild cognitive impairment or Alzheimer's disease. Journal of Aging Research, 2011, 729801. doi:10.4061/2011/729801.Google Scholar
Jolliffe, I. (1972). Discarding variables in a principal component analysis. I: artificial data. Applied Statistics, 21, 160–173.Google Scholar
Kempen, G. I. J. M., Brilman, E. I. and Ormel, J. (1995). De Mini-Mental State Examination. Tijdschrift Voor Gerontologie En Geriatrie, 26, 163–172.Google Scholar
Klein, M., Ponds, R. W., Houx, P. J. and Jolles, J. (1997). Effect of test duration on age-related differences in Stroop interference. Journal of Clinical and Experimental Neuropsychology, 19, 77–82. doi:10.1080/01688639708403838.CrossRefGoogle ScholarPubMed
Kooij, J. J. S., Buitelaar, J. K., van den Oord, E. J., Furer, J. W., Th. Rijnders, C. A. and Hodiamont, P. P. G. (2005). Internal and external validity of attention-deficit hyperactivity disorder in a population-based sample of adults. Psychological Medicine, 35, 817–827. doi:10.1017/S003329170400337X.CrossRefGoogle Scholar
Kooij, J. J. S. and Francken, M. H. (2012). Diagnostic Interview for ADHD in adults (DIVA 2.0). Springer.Google Scholar
Lezak, M., Howieson, D. and Loring, D. (1995). Neuro-psychological Assessment. Oxford: Oxford University Press.Google Scholar
Michielsen, M., Comijs, H. C., Semeijn, E. J., Beekman, A. T. F., Deeg, D. J. H. and Sandra Kooij, J. J. (2013). The comorbidity of anxiety and depressive symptoms in older adults with attention-deficit/hyperactivity disorder: a longitudinal study. Journal of Affective Disorders, 148, 220–227. doi:10.1016/j.jad.2012.11.063.CrossRefGoogle ScholarPubMed
Michielsen, M. et al. (2012). Prevalence of attention-deficit hyperactivity disorder in older adults in the Netherlands. The British Journal of Psychiatry: The Journal of Mental Science, 201, 298–305. doi:10.1192/bjp.bp.111.101196.Google Scholar
Partington, J. E. and Leiter, R. G. (1949). Partington's pathways test. Psychological Service Center Journal, 1, 11–20.Google Scholar
Paxton, J. L., Barch, D. M., Racine, C. A. and Braver, T. S. (2008). Cognitive control, goal maintenance, and prefrontal function in healthy aging. Cerebral Cortex, 18, 1010–1028. doi:10.1093/cercor/bhm135.CrossRefGoogle ScholarPubMed
Piccinin, A. M. and Rabbitt, P. M. A. (1999). Contribution of cognitive abilities to performance and improvement on a substitution coding task. Psychology and Aging, 14, 539–551. doi:10.1037/0882-7974.14.4.539.Google Scholar
Polanczyk, G. and Rohde, L. A. (2007). Epidemiology of attention-deficit/hyperactivity disorder across the lifespan. Current Opinion in Psychiatry, 20, 386–392. doi:10.1097/YCO.0b013e3281568d7a.CrossRefGoogle ScholarPubMed
Radloff, L. S. (1977). The CES-D scale: a self-report depression scale for research in the general population. Applied Psychological Measurement, 1, 385–401. doi:10.1177/014662167700100306.Google Scholar
Raven, J. C. (1995). Manual for the Coloured Progressive Matrices (revised). Windsor, UK: NFRE-Nelson.Google Scholar
Raz, N. (2000). Aging of the brain and its impact on cognitive performance: integration of structural and functional findings. In Craik, F. I. M. and Salthouse, T. A. (eds.), Handbook of Aging and Cognition, 2nd edn, (pp.1–90). Mahwah, NJ: Erlaub.Google Scholar
Rey, A. (1964). L’examen clinique en psychologie [The clinical examination in psychology]. Paris: Presse Universitaire de France.Google Scholar
Sclar, D., Robison, L. M., Bowen, K. A., Schmidt, J. M., Castillo, L. V. and Oganov, A. M. (2012). Attention-deficit/hyperactivity disorder among children in the United States: trend in diagnosis and use of pharmacotherapy by gender. Clinical Pediatrics, 51, 584–589. doi:10.1177/0009922812439621.Google Scholar
Semeijn, E. J., Michielsen, M., Comijs, H. C., Deeg, D. J. H., Beekman, A. T. F. and Kooij, J. J. S. (2013). Criterion validity of an attention deficit hyperactivity disorder (ADHD) screening list for screening ADHD in older adults aged 60–94 years. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 21, 631–635. doi:10.1016/j.jagp.2012.08.003.Google Scholar
Van den Kommer, T. N., Comijs, H. C., Aartsen, M. J., Huisman, M., Deeg, D. J. H. and Beekman, A. T. F. (2013). Depression and cognition: how do they interrelate in old age? The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 21, 398–410. doi:10.1016/j.jagp.2012.12.015.Google Scholar
Walitza, S. et al. (2007). Association of Parkinson's disease with symptoms of attention deficit hyperactivity disorder in childhood. Journal of Neural Transmission, 72 (Suppl.), 311–315.Google Scholar
Wechsler, D. (1987). Wechsler Adult Intelligence Scale-Revised. Manual. New York: Psychological Corporation.Google Scholar
Woods, S. P., Lovejoy, D. W. and Ball, J. D. (2002). Neuropsychological characteristics of adults with ADHD: a comprehensive review of initial studies. The Clinical Neuropsychologist, 16, 12–34. doi:10.1076/clin.16.1.12.8336.Google Scholar