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Does plasma phoenixin level associate with cognition? Comparison between subjective memory complaint, mild cognitive impairment, and mild Alzheimer's disease

Published online by Cambridge University Press:  29 May 2017

Mehmet Yuruyen ,
Gozde Gultekin ,
Gizem Cetiner Batun ,
Hakan Yavuzer ,
Fundan Engin Akcan ,
Alper Doventas  and
Murat Emul
Mehmet Yuruyen
Affiliation:
Department of Internal Medicine, Medical School of Cerrahpasa, Istanbul University, Istanbul, Turkey
Gozde Gultekin*
Affiliation:
Department of Psychiatry, Medical School of Cerrahpasa, Istanbul University, Istanbul, Turkey
Gizem Cetiner Batun
Affiliation:
Department of Psychiatry, Medical School of Cerrahpasa, Istanbul University, Istanbul, Turkey
Hakan Yavuzer
Affiliation:
Department of Internal Medicine, Medical School of Cerrahpasa, Istanbul University, Istanbul, Turkey
Fundan Engin Akcan
Affiliation:
Department of Psychiatry, Medical School of Cerrahpasa, Istanbul University, Istanbul, Turkey
Alper Doventas
Affiliation:
Department of Internal Medicine, Medical School of Cerrahpasa, Istanbul University, Istanbul, Turkey
Murat Emul
Affiliation:
Department of Psychiatry, Medical School of Cerrahpasa, Istanbul University, Istanbul, Turkey
*
Correspondence should be addressed to: Gozde Gultekin, MD, Department of Psychiatry, Medical School of Cerrahpasa, Istanbul University, Istanbul, Turkey. Phone: +90 5379825762. Emails: [email protected], [email protected].
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Abstract

Background:

Alteration in energy expenditure or metabolism is the most accused risk issue for the onset and for the course of neurodegenerative cognitive disorders. Neuropeptides are suggested to be related with learning and memory. Phoenixin (PNX) is the most recently reported neuropeptide and we aimed to compare the plasma level in people with subjective memory complaints, patients with mild cognitive impairment, and mild Alzheimer's disease (AD).

Methods:

Ninety two participants enrolled in the study. After screening tests, all participants were assessed with a neuropsychological battery for further cognitive evaluations. We used ELISA kit to assay the level of Human PNX.

Results:

Patients with AD were significantly older than people in subjective memory complaint group (p = 0.02). There was no significant difference between groups according to gender (p = 0.435). Mean plasma PNX level was not significantly different between groups (p = 0.279). Mean plasma PNX level in MCI group was positively correlated with BMI (r = 0.402 and p = 0.028), serum HDL level (r = 0.454 and p = 0.012), blood systolic pressure (r = 0.428 and p = 0.018) and negatively correlated with logical memory (r=−0.335 and p=0.031). The mean plasma PNX level was positively correlated with immediate recall in subjective memory complaint group (r = 0.417 and p = 0.034).

Conclusion:

This study is the first studying the association of plasma PNX level and cognitive complaints or decline. The knowledge about the role, interaction, and physiological functions of PNX is lacking. Lower plasma PNX level might be important in prodromal stages as MCI and the predictive role of PNX should be investigated in further studies.

Keywords

neuropeptidesphoenixincognitionleptindementiamild cognitive impairmentsubjective memory complaint
Type
Research Article
Information
International Psychogeriatrics , Volume 29 , Issue 9 , September 2017 , pp. 1543 - 1550
Copyright
Copyright © International Psychogeriatric Association 2017 

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