Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-12-01T04:13:57.645Z Has data issue: false hasContentIssue false
  • English
  • Français

Bacitracin Versus Mupirocin for Staphylococcus aureus Nasal Colonization

Published online by Cambridge University Press:  02 January 2015

Norberto E. Soto ,
Ashok Vaghjimal ,
Annette Stahl-Avicolli ,
John R. Protic ,
Larry I. Lutwick  and
Edward K. Chapnick
Norberto E. Soto*
Affiliation:
Division of Infectious Diseases, Department of Medicine, Maimonides Medical Center, Brooklyn, New York
Ashok Vaghjimal
Affiliation:
Division of Infectious Diseases, Department of Medicine, Maimonides Medical Center, Brooklyn, New York
Annette Stahl-Avicolli
Affiliation:
Department of Pharmacy, Maimonides Medical Center, Brooklyn, New York
John R. Protic
Affiliation:
Division of Microbiology, Department of Pathology, Maimonides Medical Center, Brooklyn, New York
Larry I. Lutwick
Affiliation:
Division of Infectious Diseases, Department of Medicine, Maimonides Medical Center, Brooklyn, New York
Edward K. Chapnick
Affiliation:
Division of Infectious Diseases, Department of Medicine, Maimonides Medical Center, Brooklyn, New York
*
Maimonides Medical Center, 4802 Tenth Ave, Brooklyn, NY 11219
Get access Rights & Permissions [Opens in a new window]

Abstract

We performed a randomized prospective study of 5-day treatment with topical mupirocin or bacitracin for the elimination of Staphylococcus aureus nasal colonization in healthcare workers (HCWs). Nasal cultures were obtained from 141 HCWs, 37 (26%) of whom showed S aureus. After 72 to 96 hours of treatment, the organism was eradicated in 15 (94%) of 16 by mupirocin and in 8 (44%) of 18 by bacitracin (P=.0031). Similar efficacy was demonstrated at 30 days. Mupirocin may be more effective than bacitracin for eradication of S aureus in healthy HCWs.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 20 , Issue 5 , May 1999 , pp. 351 - 353
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Doebbeling, BN, Breneman, DL, Neu, HC, Aly, R, Yangco, BG, Holley, HP Jr, et al. Elimination of Staphylococcus aureus carriage in health care workers: analysis of six clinical trials with calcium mupirocin ointment The Mupirocin Collaborative Study Group. Clin Infed Dis 1993;17:466474.Google Scholar
2. Kluytmans, JW, Manders, MJ, vanBommel, E, Verbrugh, H. Elimination of nasal carriage of Staphylococcus aureus in hemodialysis patients. Infect Control Hosp Epidemiol 1996;17:793–797.CrossRefGoogle ScholarPubMed
3. Kluytmans, JW, Mouton, JW, VandenBergh, MFQ, Manders, M-JAAJ, Maat, APWM, Wagenvoort, JHT, et al. Reduction of surgical-site infections in cardiothoracic surgery by elimination of nasal carriage of Staphylococcus aureus . Infect Control Hosp Epidemiol 1996;17:780–785.CrossRefGoogle ScholarPubMed
4. Raz, R, Mirn, D, Colodner, R Staler, Z, Samar, Z, Keneess, Y. A 1-year trial in the prevention of recurrent staphylococcal nasal colonization and skin infection. Arch Intern Med 1996;156:1109–1112.Google Scholar
5. Miller, MA Dascal, A, Portnoy, J, Mendelson, J. Development of mupirocin resistance among methicillin-resistant Staphylococcus aureus after widespread use of nasal mupirocin ointment Infect Control Hosp -Epidemiol 1996;17:811–813.CrossRefGoogle ScholarPubMed
6. Mapple, PAC, Hamilton-Miller, JMT, Brumfitt, W. World-wide antibiotic resistance in methicillin-resistant Staphylococcus aureus. Lancet 1989;i:537–540.Google Scholar
7. Chapnick, EK, Gradon, JD, Kreiswirth, B, Lutwick, LI, Schaffer, CC, Schiano, TD, et al. Comparative killing kinetics of methicillin-resistant Staphylococcus aureus by bacitracin or mupirocin. Infed Control Hosp Epidemiol 1996;17:178–180.Google Scholar
8. Bryan, CS, Wilson, RS, Meade, P, Sill, LG. Topical antibiotic ointments for staphylococcal nasal carriers: survey of current practices and comparison of bacitracin and vancomycin ointments. Infect Control 1980;1:153–156.Google Scholar
9. Roccaforte, JF, Bittner, MJ, Stumpf, CA Prehelm, LC. Attempts to eradicate methicillin-resistant Staphylococcus aureus colonization with the use of trimethoprim-sulfamethoxazole, rifampin, and bacitracin. Am J Infect Control 1988;16:141–146.CrossRefGoogle ScholarPubMed
10. Mulligan, ME, Murray-Leisure, KA Standiford, HC, et al. Methicillin-resistant Staphylococcus aureus: a consensus review of the microbiology, pathogenesis, and epidemiology with implications for prevention and management Am J Med 1993;94:313–328.Google Scholar