Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-12-01T03:32:26.205Z Has data issue: false hasContentIssue false

Management of carbapenemase-producing Enterobacteriaceae in a low incidence area: A six-year experience in a university hospital

Published online by Cambridge University Press:  17 June 2019

Audrey Emery
Affiliation:
Hygiène Hospitalière, Centre Hospitalier Régional Universitaire, Besançon, France
Audrey Jeanvoine
Affiliation:
Hygiène Hospitalière, Centre Hospitalier Régional Universitaire, Besançon, France UMR 6249 Chrono-environnement, Université de Bourgogne-Franche-Comté, Besançon, France
Pascale Bailly
Affiliation:
Hygiène Hospitalière, Centre Hospitalier Régional Universitaire, Besançon, France
Houssein Gbaguidi-Haore
Affiliation:
Hygiène Hospitalière, Centre Hospitalier Régional Universitaire, Besançon, France UMR 6249 Chrono-environnement, Université de Bourgogne-Franche-Comté, Besançon, France
Didier Hocquet
Affiliation:
Hygiène Hospitalière, Centre Hospitalier Régional Universitaire, Besançon, France UMR 6249 Chrono-environnement, Université de Bourgogne-Franche-Comté, Besançon, France Centre de Ressources Biologiques – Filière Microbiologique de Besançon, Centre Hospitalier Régional Universitaire, Besançon, France
Xavier Bertrand*
Affiliation:
Hygiène Hospitalière, Centre Hospitalier Régional Universitaire, Besançon, France UMR 6249 Chrono-environnement, Université de Bourgogne-Franche-Comté, Besançon, France
*
Author for correspondence: Xavier Bertrand, Hygiène Hospitalière, Centre Hospitalier Régional Universitaire, 3 boulevard Fleming, Besançon, Cedex 25030, France. Email: [email protected]

Abstract

We conducted a 6-year retrospective analysis of monitoring of carbapenemase-producing Enterobacteriaceae (CPE) in a large hospital in a low CPE incidence area, and we evaluated the “search and isolate” strategy implemented. In total, 40 CPE isolates were collected from 32 patients, and only 1.4% of contact patients screened were CPE carriers.

Type
Concise Communication
Copyright
© 2019 by The Society for Healthcare Epidemiology of America. All rights reserved. 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Cantón, R, Akóva, M, Carmeli, Y, et al. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect 2012;18:413431.CrossRefGoogle Scholar
HCSP. Prévention de la transmission croisée des Bactéries Hautement Résistantes aux antibiotiques émergentes (BHRe). Paris: Haut Conseil de la Santé Publique; 2013.Google Scholar
Clinical breakpoints and dosing of antibiotics EUCAST website. http://www.eucast.org/clinical_break. Published 2019. Accessed January 16, 2019.Google Scholar
Hrabák, J, Chudáčkova, E, Papagiannitsis, CC. Detection of carbapenemases in Enterobacteriaceae: a challenge for diagnostic microbiological laboratories. Clin Microbiol Infect 2014;20:839853.CrossRefGoogle ScholarPubMed
Tenover, FC, Arbeit, RD, Goering, RV, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995;33:22332239.Google ScholarPubMed
Birgand, G, Leroy, C, Nerome, S, et al. Costs associated with implementation of a strict policy for controlling spread of highly resistant microorganisms in France. BMJ Open 2016;6:e009029.CrossRefGoogle ScholarPubMed
Poirel, L, Potron, A, Nordmann, P. OXA-48-like carbapenemases: the phantom menace. J Antimicrob Chemother 2012;67:15971606.CrossRefGoogle ScholarPubMed
Potron, A, Poirel, L, Nordmann, P. Derepressed transfer properties leading to the efficient spread of the plasmid encoding carbapenemase OXA-48. Antimicrob Agents Chemother 2014;58:467471.CrossRefGoogle ScholarPubMed
De Geyter, D, Blommaert, L, Verbraeken, N, et al. The sink as a potential source of transmission of carbapenemase-producing Enterobacteriaceae in the intensive care unit. Antimicrob Resist Infect Control 2017;6:24.CrossRefGoogle ScholarPubMed