Hostname: page-component-586b7cd67f-rcrh6 Total loading time: 0 Render date: 2024-12-02T21:18:43.161Z Has data issue: false hasContentIssue false
  • English
  • Français

Gentamicin-Susceptible or Gentamicin-Resistant Methicillin-Resistant Staphylococcus aureus A Case-Case Study

Published online by Cambridge University Press:  21 June 2016

Jérôme Robert ,
Roland Bismuth ,
Nadine Lemaitre  and
Vincent Jarlier
Jérôme Robert*
Affiliation:
Bactériologie-Hygiène, Faculté de Médecine Pierre et Marie Curie–Paris 6, Site Pitié-Salpétriêre, Paris, France
Roland Bismuth
Affiliation:
Bactériologie-Hygiène, Faculté de Médecine Pierre et Marie Curie–Paris 6, Site Pitié-Salpétriêre, Paris, France
Nadine Lemaitre
Affiliation:
Bactériologie-Hygiène, Faculté de Médecine Pierre et Marie Curie–Paris 6, Site Pitié-Salpétriêre, Paris, France
Vincent Jarlier
Affiliation:
Bactériologie-Hygiène, Faculté de Médecine Pierre et Marie Curie–Paris 6, Site Pitié-Salpétriêre, Paris, France
*
Laboratoire de Bactériologie-Hygiène, Faculté de Médecine Pitié-Salpétriêre, Université Pierre et Marie Curie, 91 Boulevard de l'hôpital, 75634 Paris Cedex 13, France, ([email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

Gentamicin-susceptible methicillin-resistant Staphylococcus aureus (GS-MRSA) strains are replacing gentamicin-resistant MRSA (GR-MRSA) strains. We showed that exposure to other patients harboring GS-MRSA was the major risk factor for GS-MRSA acquisition, and that antimicrobial exposure, especially to β-lactams, was strongly associated with acquisition of GR-MRSA but not GS-MRSA. Gentamicin use was significantly associated with GR-MRSA acquisition in univariate analysis only.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 27 , Issue 8 , August 2006 , pp. 879 - 883
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Lemaitre, N, Sougakoff, W, Masmoudi, A, Fievet, MH, Bismuth, R, Jarlier, V. Characterization of gentamicin-susceptible strains of methicillin-resistant Staphylococcus aureus involved in nosocomial spread. J Clin Microbiol 1998; 36:81–85.CrossRefGoogle ScholarPubMed
2. Lelievre, H, Lina, G, Jones, M, et al. Emergence and spread in French hospitals of methicillin-resistant Staphylococcus aureus with increasing susceptibility to gentamicin and other antibiotics. J Clin Microbiol 1999; 37:3452–3457.Google Scholar
3. McGowan, JJ, Terry, P, Huang, T, Houk, C, Davies, J. Nosocomial infections with gentamicin-resistant Staphylococcus aureus: plasmid analysis as an epidemiologic tool. J Infect Dis 1979; 140:864–872.Google Scholar
4. Asensio, A, Guerrero, A, Quereda, C, Lizan, M, Martinez-Ferrer, M. Colonization and infection with methicillin-resistant Staphylococcus aureus: associated factors and eradication. Infect Control Hosp Epidemiol 1996; 17:20–28.Google Scholar
5. Bonten, MJM, Slaughter, S, Ambergen, AW, et al. The role of the “colonization pressure” in the spread of vancomycin-resistant enterococci: an important infection control variable. Arch Intern Med 1998; 158:1127–1132.Google Scholar
6. Merrer, J, Santoli, F, Appéré-De Vecchi, C, Tran, B, De Jonghe, B, Outin, H. “Colonization pressure” and risk of acquisition of methicillin-resistant Staphylococcus aureus in a medical intensive care unit. Infect Control Hosp Epidemiol 2000; 21:718–723.Google Scholar
7. Blanc, DS, Francioli, P, Le Coustumier, A, et al. Reemergence of gentamicin-susceptible strains of methicillin-resistant Staphylococcus aureus in France: a phylogenic approach. J Clin Microbiol 2001; 39:2287–2290.Google Scholar
8. Galdbart, J-O, Morvan, A, El Sohl, N. Phenotypic and molecular typing of nosocomial methicillin-resistant Staphylococcus aureus strains susceptible to gentamicin isolated in France from 1995 to 1997. J Clin Microbiol 2000; 38:185–190.Google Scholar
9. McGowan, JEJ. Antimicrobial resistance in hospital organisms and its relation to antibiotic use. Rev Infect Dis 1983; 5:1033–1048.Google Scholar
10. Jarlier, V. Bactéries multirésistantes dans les hôpitaux français: des premiers indicateurs au Réseau d'alerte d'investigation et de surveillance des infections nosocomiales (Raisin). Bull Epid Hebdo 2004;32–33:148–151.Google Scholar
11. Coello, R, Jimenez, J, Garcia, M, et al. Prospective study of infection, colonization and carriage of methicillin-resistant Staphylococcus aureus in an outbreak affecting 990 patients. Eur J Clin Microbiol Infect Dis 1994; 13:74–81.Google Scholar
12. Weber, SG, Gold, HS, Hooper, DC, Karchmer, AW, Carmeli, Y. Fluoroquinolones and the risk for methicillin-resistant Staphylococcus aureus in hospitalized patients. Emerg Infect Dis 2003; 9:1415–1422.Google Scholar
13. Young, LS, Perdreau-Remington, F, Winston, LG. Clinical, epidemiologic, and molecular evaluation of a clonal outbreak of methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis 2004; 38:1075–1083.Google Scholar
14. Chambers, H. Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications. Clin Microbiol Rev 1997; 10:781–791.Google Scholar
15. Que, Y, Entenza, J, Francioli, P, Moreillon, P. The impact of penicillinase on cefamandole treatment and prophylaxis of experimental endocarditis due to methicillin-resistant Staphylococcus aureus . J Infect Dis 1998; 177:146–154.CrossRefGoogle ScholarPubMed
16. Boyce, J, Havill, N, Kohan, C, Dumigan, D, Ligi, C. Do infection control measures work for methicillin-resistant Staphylococcus aureus?. Infect Control Hosp Epidemiol 2004; 25:395–401.Google Scholar
17. Pittet, D, Hugonnet, S, Harbarth, S, et al. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme. Lancet 2000; 356:1307–1312.Google Scholar
18. Robert, J, Fridkin, SK, Blumberg, HM, et al. The influence of the composition of the nursing staff on primary bloodstream infection rates in a surgical intensive care unit. Infect Control Hosp Epidemiol 2000; 21:12–17.Google Scholar
19. Haley, RW, Bregman, DA. The role of understaffing and overcrowding in recurrent outbreaks of staphylococcal infection in a neonatal special-care unit. J Infect Dis 1982; 145:875–885.CrossRefGoogle Scholar
20. Laurent, F, Lelievre, H, Cornu, M, et al. Fitness and competitive growth advantage of new gentamicin-susceptible MRSA clones spreading in French hospitals. J Antimicrob Chemother 2001; 47:277–283.Google Scholar