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Variation among inbred strains of mice in adenosine 3′:5′ cyclic monophosphate levels of spermatozoa

Published online by Cambridge University Press:  14 April 2009

Robert P. Erickson ,
Martin S. Butley ,
Susan R. Martin  and
Charles J. Betlach
Robert P. Erickson
Affiliation:
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 Department of Pediatrics, University of San Francisco, California 94143
Martin S. Butley
Affiliation:
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109
Susan R. Martin
Affiliation:
Department of Pediatrics, University of San Francisco, California 94143
Charles J. Betlach
Affiliation:
Department of Pediatrics, University of San Francisco, California 94143
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Spermatozoa from inbred strains of mice were found to vary significantly for levels of cyclic AMP when extractions were performed in a reproducible manner. The F1 hybrid between high and low spermatozoal cAMP strains showed spermatozoal cAMP levels typical of the low strain. An analysis of spermatozoal cAMP in individual mice from the back-cross of the F1 to the high strain suggested that alleles at more than one locus determine strain differences in spermatozoal cAMP. The major histocompatibility locus of mice, H-2, which had been found to have an effect on liver cAMP levels did not seem to affect spermatozoal cAMP levels. t-Alleles, which appear to alter fertilization rates by effects on motility, had no apparent affects on spermatozoal cAMP.

Type
Research Article
Information
Genetics Research , Volume 33 , Issue 2 , April 1979 , pp. 129 - 136
Copyright
Copyright © Cambridge University Press 1979

References

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