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Selection for growth on normal and reduced protein diets in mice: I. Direct and correlated responses for growth

Published online by Cambridge University Press:  14 April 2009

B. Vivi Hunnicke Nielsen  and
Søren Andersen
B. Vivi Hunnicke Nielsen
Affiliation:
Institute of Animal Science and Department of Mathematics, Royal Veterinary and Agricultural University, DK-1958 Frederiksberg C, Denmark
Søren Andersen
Affiliation:
Institute of Animal Science and Department of Mathematics, Royal Veterinary and Agricultural University, DK-1958 Frederiksberg C, Denmark
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Mice were selected for growth from 3 to 9 weeks of age on a normal protein diet (N) containing 19·3% protein and a reduced protein diet (R) containing 5·1% protein. On each diet there were 3 high (H), 3 low (L) and 3 unselected control (C) lines. After 6 generations of selection, half of the mice in each line were tested on each diet. Responses were obtained when selecting for both increased and decreased growth on both diets. The realized heritabilities from within-family selection were 33 and 26% for the divergences on the normal and reduced protein diets, respectively. Consistent genotype-environment interactions were found when all lines were tested on both diets in generation 7. Performance on each protein level was best improved by selection on that protein level. Further, the correlated response was significantly less than the direct response when selecting on both diets. The estimates of the genetic correlation between growth on the two protein levels were low, rN = 0·16 from selection on the normal protein diet and rR = 0·51 from selection on the reduced protein diet. Selection resulted in a change in environmental sensitivity in the lines, dependent on the diet and direction of selection. The average of the divergences on the two diets was not dependent on the selection environment.

Type
Research Article
Information
Genetics Research , Volume 50 , Issue 1 , August 1987 , pp. 7 - 15
Copyright
Copyright © Cambridge University Press 1987

References

Bailey, C. M., Hammack, S. P., Harvey, W. R. & Probert, C. L. (1970). Sire line × nutritional regimen interaction: Effects on postweaning performance of the rat. Journal of Animal Science 30, 3, 337–347.CrossRefGoogle ScholarPubMed
Bohren, B. B., Hill, W. G. & Robertson, A. (1966). Some observations on asymmetrical correlated responses to selection. Genetical Research 7, 44–57.CrossRefGoogle ScholarPubMed
Dalton, D. C. (1967). Selection for growth in mice on two diets. Animal Production 9, 425–434.Google Scholar
Falconer, D. S. (1952). The problem of environment and selection. The American Naturalist 86, 293–298.CrossRefGoogle Scholar
Falconer, D. S. (1960). Selection of mice for growth on high and low planes of nutrition. Genetical Research 1, 91–113.CrossRefGoogle Scholar
Falconer, D. S. (1973). Replicated selection for body weight in mice. Genetical Research 22, 291–321.CrossRefGoogle ScholarPubMed
Falconer, D. S. (1981). Introduction to Quantitative Genetics, 2nd edn.Longman, London.Google Scholar
Falconer, D. S. & Latyszewski, M. (1952). The environment in relation to selection for size in mice. Journal of Genetics 51, 67–80.CrossRefGoogle Scholar
Hammond, J. (1947). Animal breeding in relation to nutrition and environmental conditions. Biological Reviews 22, 195–213.CrossRefGoogle ScholarPubMed
Hetzel, D. J. S. & Nicholas, F. W. (1986). Growth, efficiency and body composition of mice selected for post-weaning weight gain on ad libitum or restricted feeding. Genetical Research 48, 101–109.CrossRefGoogle ScholarPubMed
Hill, W. G. (1972). Estimation of realised heritabilities from selection experiments I. Divergent selection Biometrics 28, 747–765.CrossRefGoogle ScholarPubMed
Hill, W. G. (1978). Design of selection experiments for comparing alternative testing regimes. Heredity 41, 3, 371–376.CrossRefGoogle Scholar
Hill, W. G. (1980). Design of quantitative genetic selection experiments. In Selection Experiments in Laboratory and Domestic Animals, pp. 1–13. Commonwealth Agricultural Bureaux.Google Scholar
Kownacki, M. (1971). Selection for large and small body size of outbred mice maintained on a high and low protein diet. Genetica Polonica 12, 4, 425–429.Google Scholar
Kownacki, M. & Gebler, E. (1974). Effect of selection and mating mice maintained on changed diets. In 1st World Congress on genetics applied to livestock production. Madrid, 7–11 10 1974, pp. 479–483.Google Scholar
McPhee, C. P., Trappett, P. C., Neill, A. R. & Duncalfe, F. (1980). Changes in growth, appetite, food conversion efficiency and body composition in mice selected for high post-weaning weight gain on restricted feeding. Theoretical and Applied Genetics 57, 49–56.CrossRefGoogle ScholarPubMed
Nielsen, B. V. & Andersen, S. (1982). The effect of dietary protein content upon growth in a genetically heterogeneous population of mice. Growth 46, 343–354.Google Scholar
Nielsen, B. V. H. (1986). Et eksperimentelt studium af genotype-miljø vekselvirkninger. Ph.D. Thesis. University of Aarhus.Google Scholar
Park, Y. I., Hansen, C. T., Chung, C. S. & Chapman, A. B. (1966). Influence of feeding regime on the effects of selection for postweaning gain in the rat. Genetics 54, 1315–1327.Google Scholar
Sørensen, P. (1977). Genotype-level of protein interaction for growth rate in broilers. British Poultry Science 18, 625–632.CrossRefGoogle Scholar
Sørensen, P. (1980). Results of selection in broilers reared on different suboptimal feeding regimes. XXII. British Poultry Breeders Roundtable.Google Scholar
Sørensen, P. (1986). Studium af effekten af selektion for vækst hos slagtekyllinger. Doctoral Thesis. Royal Veterinary and Agricultural University, Copenhagen.Google Scholar
Yüksel, E., Hill, W. G. & Roberts, R. C. (1981). Selection for efficiency of feed utilization in growing mice. Theoretical and Applied Genetics 59, 129–137.CrossRefGoogle ScholarPubMed