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Properties of the R factor R144drd3 in Klebsiella pneumoniae strain M5a1
Published online by Cambridge University Press: 14 April 2009
Summary
The R factor, R144drd3, mobilized chromosomal genes in Klebsiella pneumoniae strain M5a1 at similar frequencies to those observed for this R factor in Escherichia coli K12. In a derivative K. pneumoniae donor, strain HF3, R144 persisted in the autonomous state but now gave rise to polarized transfer of the chromosome in the order O his…arg 2…leu…trp. R144drd3 was unstable in K. pneumoniae M5a1; after successive subculture drug resistance, colicinogeny and transmissibility were lost. In strain HF3, transmissibility was preferentially lost, but determinants for drug resistance, colicinogeny and superinfection immunity were retained; 10–11 copies per chromosome of R144 were present in log phase cultures of both strains.
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- Copyright © Cambridge University Press 1975
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