Hostname: page-component-745bb68f8f-l4dxg Total loading time: 0 Render date: 2025-01-12T21:47:27.299Z Has data issue: false hasContentIssue false
  • English
  • Français

A new regulatory gene in the histidine decarboxylase gene complex determines the responsiveness of the mouse kidney enzyme to testosterone

Published online by Cambridge University Press:  14 April 2009

Richard J. Middleton ,
S. A. M. Martin  and
Grahame Bulfield
Richard J. Middleton
Affiliation:
Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian, EH25 9PS, U.K.
S. A. M. Martin
Affiliation:
Department of Genetics, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JN, U.K.
Grahame Bulfield*
Affiliation:
Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian, EH25 9PS, U.K.
*
* Corresponding authors.
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The level of histidine decarboxylase in mouse kidney normally differs between the sexes with females higher than males. In a strain derived from feral Danish mice (DAN), however, both males and females have the same, high, HDC activity due to the males being insensitive to repression by testosterone. Genetic analysis indicates that this insensitivity is caused by a variant allele of a new gene in the histidine decarboxylase gene complex, Hdc-a; the Hdc-ab allele in C57BL/10 confers high sensitivity to testosterone whereas the Hdc-aw allele in the DAN strain confers low sensitivity. In addition, the DAN strain has a novel haplotype for the other three known elements of [Hdc]: the allele Hdc-sd of the structural gene, the Hdc-cd allele of the gene determining enzyme concentration, and the oestrogen-inducible allele Hdc-eb.

Type
Research Article
Information
Genetics Research , Volume 49 , Issue 1 , February 1987 , pp. 61 - 67
Copyright
Copyright © Cambridge University Press 1987

References

Bulfield, G. & Nahum, A. (1978). Effect of the mouse mutants Testicular feminisation and Sex reversal on hormone-mediated induction and repression of enzymes. Biochemical Genetics 16, 743–750.CrossRefGoogle ScholarPubMed
Bullock, L. P. (1983). Androgen and progestin stimulation of ornithine decarboxylase activity in the mouse kidney. Endocrinology 112, 1903–1909.CrossRefGoogle ScholarPubMed
Grahn, B., Henningson, S., Kahlson, G. & Rosengren, E. (1973). Alterations in activities of ornithine and histidine decarboxylases provoked by testosterone in mice. British Journal of Pharmacology 48, 113–120.CrossRefGoogle ScholarPubMed
Kahlson, G. & Rosengren, E. (1968). New approaches to the physiology of histamine. Physiology Reviews 48, 155–196.CrossRefGoogle Scholar
Lyon, M. F. (1981). Rules and guidelines for gene nomenclature. In Genetic Variants and Strains of the Laboratory Mouse (ed. Green, M. C.), pp. 107. New York, Stuttgart: Gustav Fischer-Verlag.Google Scholar
Martin, S. A. M. & Bulfield, G. (1984 a). A structural gene (Hdc-s) for mouse histidine decarboxylase. Biochemical Genetics 22, 645–655.CrossRefGoogle ScholarPubMed
Martin, S. A. M. & Bulfield, G. (1984 b). A regulatory locus, Hdc-e, determines the response of mouse kidney histidine decarboxylase to estrogen. Biochemical Genetics 22, 1037–1046.CrossRefGoogle ScholarPubMed
Martin, S. A. M. & Bulfield, G. (1986). Genetic analysis of a new haplotype of the histidine decarboxylase gene complex in C57BL/6 mice. Genetical Research 47, 131–134.CrossRefGoogle ScholarPubMed
Martin, S. A. M., Taylor, B. A., Watanabe, T. & Bulfield, G. (1984). Histidine decarboxylase phenotypes of inbred mouse strains: a regulatory locus (Hdc) determines kidney enzyme concentration. Biochemical Genetics 22, 305–322.CrossRefGoogle ScholarPubMed
Pajunen, A. E., Isomaa, V. V., Janne, O. A. & Bardin, C. W. (1982). Androgenic regulation of ornithine decarboxylase in mouse kidney and its relationship to changes in cytosol and nuclear androgen receptor changes. Journal of Biological Chemistry 257, 8190–8198.CrossRefGoogle Scholar
Pfister, K., Paigen, K., Watson, G. & Chapman, V. (1982). Expression of β-glucuronidase haplotypes in prototype and congenic mouse strains. Biochemical Genetics 20, 519–536.CrossRefGoogle ScholarPubMed
Rosengren, E. (1962). Formation of histamine in the pregnant mouse. Experientia 18, 176–177.CrossRefGoogle ScholarPubMed