Hostname: page-component-586b7cd67f-t7fkt Total loading time: 0 Render date: 2024-11-24T12:31:43.477Z Has data issue: false hasContentIssue false
  • English
  • Français

Knobbly, a new dominant mutation in the mouse that affects embryonic ectoderm organization

Published online by Cambridge University Press:  14 April 2009

R. J. Jacobs-Cohen ,
M. Spiegelman ,
J. C. Cookingham  and
D. Bennett
R. J. Jacobs-Cohen
Affiliation:
Laboratory of Developmental Genetics, Sloan-Kettering Institute for Cancer Research, New York, New York 10021
M. Spiegelman
Affiliation:
Laboratory of Developmental Genetics, Sloan-Kettering Institute for Cancer Research, New York, New York 10021
J. C. Cookingham
Affiliation:
Laboratory of Developmental Genetics, Sloan-Kettering Institute for Cancer Research, New York, New York 10021
D. Bennett
Affiliation:
Laboratory of Developmental Genetics, Sloan-Kettering Institute for Cancer Research, New York, New York 10021
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Knobbly, FuKb, a dominant mutation on chromosome 17 of the mouse, causes a kinked tail in heterozygotes and embryonic lethality at about nine days in homozygotes. Abnormal organization of the embryonic ectoderm is first apparent at about embryonic day 7, and the retarded and malformed embryos die by mid 9 days.

Kink, FuKi, a dominant gene that maps in the same region, is also an embryonic lethal in homozygotes; heterozygotes have kinked tails and often a circling gait. We have shown FuKb and FuKi are allelic; the FuKb / FuKi compound dies at the same time as FuKb / FuKb embryos with the same morphological syndrome.

The FuKb phenotype is not seen in offspring in expected ratios. The FuKb males may have a low transmission ratio or penetrance may be incomplete.

An incidental finding of our histological studies is a high incidence of complete twinning when FuKb heterozygotes mate inter se or when FuKb × FuKi matings are made.

Type
Research Article
Information
Genetics Research , Volume 43 , Issue 1 , February 1984 , pp. 43 - 50
Copyright
Copyright © Cambridge University Press 1984

References

REFERENCES

Bennett, D. (1975). The T/t-locus of the mouse. Cell 6, 441–454.CrossRefGoogle Scholar
Caspari, E. & David, P. R. (1940). The inheritance of a tail abnormality in the house mouse. Journal of Heredity 31, 427–431.CrossRefGoogle Scholar
Dunn, L. C. & Caspari, E. (1945). A case of neighboring loci with similar effects. Genetics 30, 543–568.CrossRefGoogle ScholarPubMed
Dunn, L. C. & Gluecksohn-Waelsch, S. (1954). A genetical study of the mutation ‘Fused’ in the house mouse, with evidence concerning its allelism with a similar mutation ‘Kink’. Journal of Genetics 52, 383–391.CrossRefGoogle Scholar
Gleucksohn-Schoenheimer, S. (1949). The effects of a lethal mutation responsible for duplications and twinning in mouse embryos. Journal of Experimental Zoology 110, 47–76.CrossRefGoogle Scholar
Lyon, M. F. (1977). Mouse News Letter 56, 37.Google Scholar
Lyon, M. F. & Bechtol, K. B. (1977). Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion. Genetical Research 30, 63–76.CrossRefGoogle ScholarPubMed
Lyon, M. F. (1978). Mouse News Letter 59, 21.Google Scholar
Reed, S. C. (1937). The inheritance and expression of Fused, a new mutation in the house mouse. Genetics 22, 1–13.CrossRefGoogle ScholarPubMed
Sobotta, J. (1911). Die Entwicklung des Eies der Maus vom ersten Auftreten des Mesoderms an bis zur Ausbildung der Embryonenanlage und dem Auftreten der Allantois. Archiv für microscopische Anatomie und Entwicklungsmechanik 78, 271–352.CrossRefGoogle Scholar
Theiler, K. & Gluecksohn-Waelsch, S. (1956). The morphological effects and the development of the Fused mutation in the mouse. Anatomical Record 125, 83–104.CrossRefGoogle ScholarPubMed
Theiler, K. (1972). The House Mouse. New York: Springer Verlag.Google Scholar