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Preclinical activities of Cassia tora Linn against aging-related diseases

Published online by Cambridge University Press:  25 October 2022

Sun-Young Hwang
Affiliation:
College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea
Chang-Su Na
Affiliation:
College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea
Byeong Cheol Moon
Affiliation:
Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju 58245, Republic of Korea
Jung-Hyun Shim*
Affiliation:
Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam 58554, Republic of Korea Department of Biomedicine, Health & Life Convergence Sciences, BK21 FOUR, Mokpo National University, Jeonnam 58554, Republic of Korea The China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan 450008, P.R. China
Mee-Hyun Lee*
Affiliation:
College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea
*
Authors for correspondence: Jung-Hyun Shim, E-mail: [email protected], Mee-Hyun Lee, E-mail: [email protected] ([email protected])
Authors for correspondence: Jung-Hyun Shim, E-mail: [email protected], Mee-Hyun Lee, E-mail: [email protected] ([email protected])

Abstract

Globally, an aging population is increasing, and aging is a natural physiological process and a major risk factor for all age-related diseases. It seriously threatens personal health and imposes a great economic burden. Therefore, there is a growing scientific interest in strategies for well-aging with prevention and treatment of age-related diseases. The seed, root, stem or leaves of Cassia tora Linn. are useful for anti-bacteria, anti-hyperlipidemia and anti-obesity due to its pharmacological activities such as anti-inflammation and anti-oxidant both in vitro and in vivo. Nevertheless, no clinical trials have been attempted so far, therefore here we would like to understand the current preclinical activities for aging-related disease models including cataract, metabolic dysfunction and neurodegeneration, then discuss their preparation for clinical trials and perspectives.

Type
Review
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

Authors have equally contributed.

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