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Preclinical activities of Cassia tora Linn against aging-related diseases

Published online by Cambridge University Press:  25 October 2022

Sun-Young Hwang
Affiliation:
College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea
Chang-Su Na
Affiliation:
College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea
Byeong Cheol Moon
Affiliation:
Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju 58245, Republic of Korea
Jung-Hyun Shim*
Affiliation:
Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam 58554, Republic of Korea Department of Biomedicine, Health & Life Convergence Sciences, BK21 FOUR, Mokpo National University, Jeonnam 58554, Republic of Korea The China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan 450008, P.R. China
Mee-Hyun Lee*
Affiliation:
College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea
*
Authors for correspondence: Jung-Hyun Shim, E-mail: [email protected], Mee-Hyun Lee, E-mail: [email protected] ([email protected])
Authors for correspondence: Jung-Hyun Shim, E-mail: [email protected], Mee-Hyun Lee, E-mail: [email protected] ([email protected])

Abstract

Globally, an aging population is increasing, and aging is a natural physiological process and a major risk factor for all age-related diseases. It seriously threatens personal health and imposes a great economic burden. Therefore, there is a growing scientific interest in strategies for well-aging with prevention and treatment of age-related diseases. The seed, root, stem or leaves of Cassia tora Linn. are useful for anti-bacteria, anti-hyperlipidemia and anti-obesity due to its pharmacological activities such as anti-inflammation and anti-oxidant both in vitro and in vivo. Nevertheless, no clinical trials have been attempted so far, therefore here we would like to understand the current preclinical activities for aging-related disease models including cataract, metabolic dysfunction and neurodegeneration, then discuss their preparation for clinical trials and perspectives.

Type
Review
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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Footnotes

*

Authors have equally contributed.

References

Nations, U (2022) World Population Prospects 2022. In, United Nations, New York.Google Scholar
Chung, HY et al. (2006) The molecular inflammatory process in aging. Antioxidants & Redox Signaling 8, 572581.CrossRefGoogle ScholarPubMed
Hwang, SY et al. (2020) Alternative options for skin cancer therapy via regulation of AKT and related signaling pathways. International Journal of Molecular Sciences 21, 6869.CrossRefGoogle ScholarPubMed
Pandey, A et al. (2011) Alternative therapies useful in the management of diabetes: a systematic review. Journal of Pharmacy & Bioallied Sciences 3, 504512.Google ScholarPubMed
Benchennouf, A et al. (2017) Phytochemical analysis and antioxidant activity of Lycium barbarum (Goji) cultivated in Greece. Pharmaceutical Biology 55, 596602.CrossRefGoogle ScholarPubMed
Tzeng, TF et al. (2013) Cassia tora (Leguminosae) seed extract alleviates high-fat diet-induced nonalcoholic fatty liver. Food and Chemical Toxicology 51, 194201.CrossRefGoogle ScholarPubMed
Xie, B et al. (2019) Sequencing and phylogenetic analysis of the complete chloroplast genome of Cassia tora Linn. Mitochondrial DNA. Part B, Resources 4, 40274028.CrossRefGoogle ScholarPubMed
Park, SI et al. (2019) Effect of seed of Cassia tora extract in the prevention of remote renal reperfusion injury. Transplantation Proceedings 51, 28332837.CrossRefGoogle ScholarPubMed
Niculet, E et al. (2020) Influence of phytochemicals in induced psoriasis (Review). Experimental and Therapeutic Medicine 20, 34213424.Google ScholarPubMed
Aryal, S et al. (2019) Total phenolic content, flavonoid content and antioxidant potential of wild vegetables from Western Nepal. Plants (Basel) 8, 96.CrossRefGoogle ScholarPubMed
Khalifa, SAM et al. (2021) Screening for natural and derived bio-active compounds in preclinical and clinical studies: one of the frontlines of fighting the coronaviruses pandemic. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 85, 153311.CrossRefGoogle ScholarPubMed
Sreelakshmi, V and Abraham, A (2016) Polyphenols of Cassia tora leaves prevents lenticular apoptosis and modulates cataract pathology in Sprague-Dawley rat pups. Biomedicine & Pharmacotherapy 81, 371378.CrossRefGoogle ScholarPubMed
Subash-Babu, P and Alshatwi, AA (2018) Ononitol monohydrate enhances PRDM16 & UCP-1 expression, mitochondrial biogenesis and insulin sensitivity via STAT6 and LTB4R in maturing adipocytes. Biomedicine & Pharmacotherapy 99, 375383.CrossRefGoogle ScholarPubMed
Vats, S (2018) Larvicidal activity and in vitro regulation of rotenoids from Cassia tora L. 3 Biotech 8, 13.CrossRefGoogle ScholarPubMed
Ko, E et al. (2020) Cassia tora seed improves pancreatic mitochondrial function leading to recovery of glucose metabolism. American Journal of Chinese Medicine 48, 615629.CrossRefGoogle ScholarPubMed
Sreelakshmi, V and Abraham, A (2017) Protective effects of Cassia tora leaves in experimental cataract by modulating intracellular communication, membrane co-transporters, energy metabolism and the ubiquitin-proteasome pathway. Pharmaceutical Biology 55, 12741282.CrossRefGoogle ScholarPubMed
Sreelakshmi, V and Abraham, A (2016) Cassia tora leaves modulates selenite cataract by enhancing antioxidant status and preventing cytoskeletal protein loss in lenses of Sprague Dawley rat pups. Journal of Ethnopharmacology 178, 137143.CrossRefGoogle ScholarPubMed
Colca, JR and Scherer, PE (2021) The metabolic syndrome, thiazolidinediones, and implications for intersection of chronic and inflammatory disease. Molecular Metabolism 55, 101409.CrossRefGoogle ScholarPubMed
Awasthi, VK et al. (2015) Hypolipidemic activity of Cassia tora seeds in hyperlipidemic rats. Indian Journal of Clinical Biochemistry 30, 7883.CrossRefGoogle ScholarPubMed
Kumar, V et al. (2017) Experimental validation of antidiabetic and antioxidant potential of Cassia tora (L.): an indigenous medicinal plant. Indian Journal of Clinical Biochemistry 32, 323328.CrossRefGoogle Scholar
Lee, GY et al. (2015) Constituents of the seeds of Cassia tora with inhibitory activity on soluble expoxide hydrolease. Bioorganic & Medicinal Chemistry Letters 25, 50975101.CrossRefGoogle ScholarPubMed
Shamji, MH et al. (2021) The role of allergen-specific IgE, IgG and IgA in allergic disease. Allergy 76, 36273641.CrossRefGoogle ScholarPubMed
Ravi, SK et al. (2019) Cassia tora prevents Abeta1–42 aggregation, inhibits acetylcholinesterase activity and protects against Abeta1-42-induced cell death and oxidative stress in human neuroblastoma cells. Pharmacological Reports 71, 11511159.CrossRefGoogle Scholar
Chethana, KR et al. (2017) Cassia tora Linn.: a boon to Alzheimer's disease for its anti-amyloidogenic and cholinergic activities. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 33, 4352.CrossRefGoogle Scholar
Ravi, SK et al. (2020) Cassia tora extract alleviates Abeta1-42 aggregation processes in vitro and protects against aluminium-induced neurodegeneration in rats. Journal of Pharmacy and Pharmacology 72, 11191132.CrossRefGoogle Scholar
Ravi, SK et al. (2018) Neuroprotective effects of Cassia tora against paraquat-induced neurodegeneration: relevance for Parkinson's disease. Natural Product Research 32, 14761480.CrossRefGoogle ScholarPubMed
Kim, M et al. (2015) Cassia tora seed extract and its active compound aurantio-obtusin inhibit allergic responses in IgE-mediated mast cells and anaphylactic models. Journal of Agricultural and Food Chemistry 63, 90379046.Google ScholarPubMed
Lee, EK et al. (2020) Inhibitory effects of AF-343, a mixture of Cassia tora L., Ulmus pumila L., and Taraxacum officinale, on compound 48/80–mediated allergic responses in RBL-2H3 cells. Molecules 25, 2434.CrossRefGoogle Scholar
Organization, WH (2021) World malaria report 2021. In.Google Scholar
Shukla, S et al. (2018) Fatty acid composition and antibacterial potential of Cassia tora (leaves and stem) collected from different geographic areas of India. Journal of Food and Drug Analysis 26, 107111.CrossRefGoogle ScholarPubMed
Mbatchou, VC et al. (2017) Mosquito larvicidal activity of Cassia tora seed extract and its key anthraquinones aurantio-obtusin and obtusin. Parasites & Vectors 10, 562.CrossRefGoogle ScholarPubMed
Yang, J et al. (2021) Predicting the potential toxicity of 26 components in Cassiae semen using in silico and in vitro approaches. Current Research in Toxicology 2, 237245.CrossRefGoogle ScholarPubMed
Jiang, LL et al. (2018) CYP3A Activation and glutathione depletion aggravate emodin-induced liver injury. Chemical Research in Toxicology 31, 10521060.CrossRefGoogle ScholarPubMed
Lee, MJ et al. (2019) Subchronic toxicity evaluation of ethanol extract of Cassia tora L. seeds in rats. Regulatory Toxicology and Pharmacology 109, 104487.CrossRefGoogle Scholar