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Competing Endogenous RNAs (ceRNAs) in Colorectal Cancer: A Review

Published online by Cambridge University Press:  24 June 2022

Mohammad Hossein Akhbari ,
Zahra Zafari  and
Mohsen Sheykhhasan Open the ORCID record for Mohsen Sheykhhasan [Opens in a new window]
Mohammad Hossein Akhbari
Affiliation:
Department of Biology, Shahed University, Tehran, Iran
Zahra Zafari*
Affiliation:
Department of Biology, Shahed University, Tehran, Iran
Mohsen Sheykhhasan*
Affiliation:
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Department of Mesenchymal Stem Cells, Academic Center for Education, Culture and Research (ACECR), Qom Branch, Qom, Iran
*
Authors for correspondence: Zahra Zafari, E-mail: [email protected]; Mohsen Sheykhhasan, E-mail: [email protected]
Authors for correspondence: Zahra Zafari, E-mail: [email protected]; Mohsen Sheykhhasan, E-mail: [email protected]
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Abstract

Colorectal cancer (CRC) is a common type of cancer and the second leading cause of cancer-related deaths worldwide. Competing endogenous RNAs (ceRNAs) that contain microRNA response elements (MREs) are involved in CRC progression. They can compete with microRNAs (miRNAs) via their MREs, which can combine non-coding and coding RNAs via complex ceRNA networks. This molecular interaction has the potential to affect a wide variety of biological processes, and many cancers can occur as a result of an imbalanced ceRNA network. Recent research indicates that numerous dysregulated RNAs in CRC may function as ceRNAs, regulating multiple biological functions of the tumour, including proliferation, apoptosis, metastasis, invasion and migration. In this review, we discuss the role of protein-coding and non-coding RNAs, such as long non-coding RNAs, circular RNAs and pseudogenes, in the occurrence of ceRNA networks in CRC, and their function in cancer-related pathways, such as Wnt/β-catenin, mitogen-activated protein kinase and transforming growth factor-β signalling pathways. Additionally, we discuss validated ceRNAs associated with CRC biological functions and their potential role as novel prognostic and diagnostic biomarkers. Examining the role of ceRNAs in CRC sheds new light on cancer treatment and pathogenesis.

Keywords

Circular RNAscolorectal cancercompeting endogenous RNAslong non-coding RNAspseudogenes
Type
Review
Information
Expert Reviews in Molecular Medicine , Volume 24 , 2022 , e27
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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