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Angiopoietin-like-2: a multifaceted protein with physiological and pathophysiological properties

Published online by Cambridge University Press:  24 November 2014

Nathalie Thorin-Trescases  and
Eric Thorin
Nathalie Thorin-Trescases*
Affiliation:
Faculty of Medicine, Montreal Heart Institute, Research Center, University of Montreal, Montreal, Canada
Eric Thorin
Affiliation:
Faculty of Medicine, Montreal Heart Institute, Research Center, University of Montreal, Montreal, Canada Department of Surgery, Montreal, Canada.
*
*Corresponding author: Nathalie Thorin-Trescases, Montreal Heart Institute, Research Center, 5000 rue Bélanger Est, H1 T 1C8, Montreal, Quebec, Canada. E-mail: [email protected]
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Abstract

Angptl2 is a multifaceted protein, displaying both physiological and pathological functions, in which scientific and clinical interest is growing exponentially within the past few years. Its physiological functions are not well understood, but angptl2 was first acknowledged for its pro-angiogenic and antiapoptotic capacities. In addition, angptl2 can be considered a growth factor, since it increases survival and expansion of hematopoietic stem cells and may promote vasculogenesis. Finally, angptl2 has an important, but largely unrecognised, physiological role: in the cytosol, angptl2 binds to type 1A angiotensin II receptors and induces their recycling, with recovery of the receptor signal functions. Despite these important physiological properties, angptl2 is better acknowledged for its deleterious pro-inflammatory properties and its contribution in multiple chronic diseases such as cancer, diabetes, atherosclerosis, metabolic disorders and many other chronic diseases. This review aims at presenting an updated description of both the beneficial and deleterious biological properties of angptl2, in addition to its molecular signalling pathways and transcriptional regulation. The multiplicity of diseases in which angptl2 contributes makes it a new highly relevant clinical therapeutic target.

Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 16 , 2014 , e17
Copyright
Copyright © Cambridge University Press 2014 

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