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A specific “at risk” profile related to recent stressful life events in euthymic major depressive disorder

Published online by Cambridge University Press:  13 August 2021

G. Serafini ,
X. Gonda ,
A. Aguglia ,
A. Amerio ,
G. Canepa ,
P. Geoffroy ,
M. Pompili  and
M. Amore
G. Serafini*
Affiliation:
Department Of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health (dinogmi), University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy
X. Gonda
Affiliation:
Department Of Psychiatry And Psychotherapy, Semmelweis University, Budapest, Hungary
A. Aguglia
Affiliation:
Department Of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health (dinogmi), University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy
A. Amerio
Affiliation:
Department Of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health (dinogmi), University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy
G. Canepa
Affiliation:
Department Of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health (dinogmi), University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy
P. Geoffroy
Affiliation:
Psychiatry And Addiction Medicine Department, Hôpital Bichat Claude-Bernard, Assistance Publique - Hôpitaux de Paris, Paris, France
M. Pompili
Affiliation:
Departement Of Neurosciences, Mental Health And Sensory Organs, Sapienza University of Rome, Rome, Italy
M. Amore
Affiliation:
Department Of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal And Child Health (dinogmi), Departimento di Neuroscienze, Università di Genova, Genoa, Italy
*
*Corresponding author.

Abstract

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Introduction

Stressful life events (SLE) may influence the illness course and outcome.

Objectives

The present study aimed to characterize socio-demographic and clinical characteristics of euthymic major depressive disorder (MDD) outpatients with SLE relative to those without.

Methods

This sample included 628 (mean age=55.1 ± 16.1) currently euthymic MDD outpatients, among them 250 (39.8%) reported SLE and 378 (60.2%) did not.

Results

After univariate analyses, outpatients with SLE were most frequently widowed and lived predominantly with friends/others. Furthermore, compared to outpatients without SLE, those with SLE were more likely to have a family history of suicidal behavior, manifested melancholic characteristics and higher Coping Orientation to the Problems Experienced (COPE) positive reinterpretation/growth and less likely to manifest a comorbid panic disorder, residual interepisodic symptoms, have used psychiatric medications, and use current antidepressant medications. After regression analyses, having a family history of suicide (OR=9.697; p=≤.05), history of psychotropic medications use (OR=2.888; p=≤.05), and reduced use of antidepressants (OR=.321; p=.001) were significantly associated with SLE. Mediation analyses demonstrated that the association between current use of antidepressants and SLE was mediated by previous psychiatric medications.

Conclusions

Having a family history of suicide, history of psychotropic medications use, and reduced use of antidepressants may confer a specific “at risk” profile related to the enhanced vulnerability to experience SLE.

Disclosure

No significant relationships.

Keywords

Antidepressantsmajor depressive disorderfamily history of suicidenegative distressing/stressful life events
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S108 - S109
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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