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S14.02 - Imaging serotonergic and dopaminergic neurocircuits in eating disorders: New insight into behavior and treatment

Published online by Cambridge University Press:  16 April 2020

U.F. Bailer ,
G.K. Frank ,
J.C. Price ,
C.C. Meltzer ,
C.A. Mathis ,
A. Wagner  and
W.H. Kaye
U.F. Bailer
Affiliation:
Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University of Vienna, Vienna, Austria
G.K. Frank
Affiliation:
Laboratory for Developmental Brain Research, University of Colorado At Denver and Health Sciences Center, The Children's Hospital, Denver, CO, USA
J.C. Price
Affiliation:
Department of Radiology, Presbyterian University Hospital, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
C.C. Meltzer
Affiliation:
Department of Radiology, Presbyterian University Hospital, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA Departments of Radiology and Neurology, Emory School of Medicine, Atlanta, GA, USA
C.A. Mathis
Affiliation:
Department of Radiology, Presbyterian University Hospital, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
A. Wagner
Affiliation:
Department of Child and Adolescent Psychiatry, J.W. Goethe University of Frankfurt/Main, Frankfurt/Main, Germany
W.H. Kaye
Affiliation:
Western Psychiatric Institute & Clinic, University of Pittsburgh, Pittsburgh, PA, USA Department of Psychiatry, University of California San Diego, la Jolla, CA, USA

Abstract

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Several lines of evidence suggest disturbances of serotonin (5-HT) and dopamine (DA) pathways play a role in the pathogenesis and pathophysiology of anorexia nervosa (AN) and bulimia nervosa (BN). Studies using imaging with radioligands specific for 5HT and DA components, have found alterations of the 5-HT1A and 5-HT2A receptors, and DA D2/D3 receptors in AN and BN. In addition, some studies suggest relationships between these components and traits often found in individuals with AN and BN, such as harm avoidance and drive for thinness. Moreover, subtypes may have different patterns of 5-HT-DA dysfunction which may shed light on understanding specific symptoms such as inflexibility and rigidity and disregard of normal rewards in AN, or unstable mood and impulse dyscontrol in BN. The 5HT and DA systems are highly complex. Thus disturbances of these components may reflect dysregulation of these neuronal systems, rather than identify the exact etiology. In summary, new technologies such as PET and/or fMRI offer the promise of understanding the relationship of behavior and neurocircuits contributing to ED. Futhermore PET and radioligand studies may be a useful tool for investigating and managing medication response in treatment resistant individuals.

Type
Symposium: Eating disorders
Information
European Psychiatry , Volume 23 , Issue S2: 16th AEP Congress - Abstract book - 16th AEP Congress , April 2008 , pp. S22
Copyright
Copyright © European Psychiatric Association 2008
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