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The role of serotonin in depression and anxiety

Published online by Cambridge University Press:  16 April 2020

JFW Deakin
JFW Deakin*
Affiliation:
University Department of Psychiatry, Rawnsley Building, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
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Summary

The different coping responses to three types of aversive events - future threats, acute events and chronic stress — may be modulated by 5HT projections. Dysfunction in these coping mechanisms could cause, respectively: generalised anxiety disorder, panic, and depression. This theory proposes that dorsal raphe nucleus projections to 5HT2 and 5HT1D receptors mediate anticipatory anxiety and normally motivate avoidance of threats. The brain aversion system may be held in check by dorsal raphe nucleus 5HT projections to mediate behavioural inhibition during anticipatory anxiety. Proximal aversive stimuli such as pain and asphyxia elicit the fight-flight reflex mediated by the amygdala-hypothalamic-periaqueductal grey brain aversion system. Panic attacks may thus be due to spontaneous activation of this system. Median raphe projections to 5HT1A receptors have been implicated in adaptation to chronic stress-resilence. There is good evidence that 5HT1A function breaks down in depression and causes the depressed state. Experimental tests of this theory suggest that viewing anxiety, panic, and depression as dysfunctions in neurochemically and anatomically specific coping systems is heuristically useful.

Keywords

anxietydepressionpanic disorderserotonin
Type
Research Article
Information
European Psychiatry , Volume 13 , Issue S2 , 1998 , pp. 57s - 63s
Copyright
Copyright © Elsevier, Paris 1998

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References

Deakin, JFWRoles of serotoninergic systems in escape, avoidance and other behavioursCooper, SJTheory in Psychopharmacology Vol 2 1983 Academic Press London149–193Google Scholar
Deakin, JFW5HT receptors subtypes in depressionBevan, P, Cools, AR, Archer, TBehavioural pharmacology of 5HT 1989 Lawrence Erlbaum Associates New York179–204Google Scholar
Deakinj, FW, Pennell, I, Upadhyaya, AK, Lofthouse, RA neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation Psychopharmacology 4 1990 357–360Google Scholar
Deakin, JFW, Graeff, FG5-HT and mechanisms of defence J Psychopharmacol 5 1991 305–315CrossRefGoogle ScholarPubMed
Deakin, JFW, Strickland, PL, Dixon, J, Percival, C, Gater, R, Goldberg, DSocial stress, steroid levels, 5-HT and depression J Psychopharmacology 11suppl 31997 A93Google Scholar
Delgado, PL, Charney, DS, Price, LH, Aghajanian, GK, Landis, H, Heninger, GRSerotonin function and the mechanism of antidepressant action Arch Gen Psychiatry 47 1990 411–418CrossRefGoogle ScholarPubMed
Graeff, FGBrain defence systems and anxietyRoth, M, Burrows, GD, Noyes, RHandbook of Anxiety Vol 3 1990 Elsevier Science Publishers Hillsdale307–354Google Scholar
Guimaraes, FS, Zuardi, AW, Graeff, FGEffect of clomipramine and maprotiline on experimental anxiety in humans J Psychopharmacol 1 1987 184–192CrossRefGoogle Scholar
Guimaraes, FS, Kohem, CL, Gus, Get alA simple simulated public speaking test for evaluating anxiolytic drugs Braz J Med Biol Res 22 1989 1083–1089Google ScholarPubMed
Hetem, LAB, de Souza, CJ, Guimaraes, FS, Zuardi, AW, Graeff, FGEffect of d-fenfluramine on human experimental anxiety Psychopharmacology 127 1996 276–282CrossRefGoogle ScholarPubMed
Kennett, GA, Dickinson, S, Curzon, GAntidepressant-like action of some 5-HT dependent behavioural responses following repeated immobilization in rats Brain Res 330 1985 253–263CrossRefGoogle Scholar
Woods, SW, Charney, DS, Goodman, WK, Heninger, GRCarbon dioxide-induced anxiety. Behavioral, physiologic, and biochemical effects of carbon dioxide in patients with panic disorders and healthy subjects Arch Gen Psychiatry 45 1988 43–52CrossRefGoogle ScholarPubMed
Zuardi, AW, Cosme, RA, Graeff, FG, Guimaraes, FSEffects of ipsapirone and cannabidiol on human experimental anxiety J Psychopharmacology 7 1993 82–88CrossRefGoogle ScholarPubMed
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