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Psychotic symptoms in danon disease: A clinical case report

Published online by Cambridge University Press:  13 August 2021

C. Massaneda Tuneu ,
V. Soria  and
J. Gascón-Bayarri
C. Massaneda Tuneu*
Affiliation:
1. department Of Psychiatry, Bellvitge University Hospital- IDIBELL, Hospitalet del Llobregat, Barcelona, Spain
V. Soria
Affiliation:
1. department Of Psychiatry, Bellvitge University Hospital- IDIBELL, Hospitalet del Llobregat, Barcelona, Spain Faculty Of Medicine And Health Sciences, University of Barcelona, Barcelona, Spain 4. network Center For Biomedical Research On Mental Health (cibersam), Carlos III Health Institute (ISCIII), Barcelona, Spain
J. Gascón-Bayarri
Affiliation:
Department Of Neurology, Bellvitge University Hospital-IDIBELL, Hospitalet del Llobregat, Barcelona, Spain
*
*Corresponding author.

Abstract

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Introduction

Danon disease is an X-linked cardioskeletal myopathy related to a primary deficiency in lysosome-associated membrane protein-2. Danon disease manifests with the triad of hypertrophic cardiomyopathy, myopathy and intellectual disability.Psychiatric symptoms related to the disease have only been studied in a few case reports (Hatz et al, 2010 and Tanidir et al, 2015) and a case series (Yardeni et al, 2016), leaving its pathophysiological mechanisms understudied.

Objectives

Provide scientific data on psychotic symptoms in patients with Danon disease.

Methods

We report an unusual case of a 25-year-old-patient affected by Danon disease that showed an acute psychotic episode.

Results

Mr P is a 25 year-old white male, with past medical history for Danon disease. Mr P presents hypertrophic cardiomyopathy, Wolf Parkinson White arrhythmia and carries an implantable cardioverter-defibrillator. There are previous records of mild intellectual disability and the patient had experienced anxiety symptoms as well as obsessive thoughts in the past without receiving any specific diagnosis or treatment. He was admitted to the Neurology inpatient unit to study behavioural symptoms with atypical visual and auditory hallucinations, accompanied by paranoid delusions during the last 4 days. He was examined by the liaison psychiatric team. Psychosis remitted within 72 hours after introducing risperidone 3mg per day, with good tolerability. Magnetic resonance imaging (MRI) scan was normal.

Conclusions

Danon disease is caused by heterogeneity genetic mutation which means that patients can present different levels of clinical manifestations. The current case report highlights the variety of psychiatric symptoms in patients with Danon disease, and raises awareness towards its identification and treatment.

Disclosure

No significant relationships.

Keywords

psychosisneurologydanon disease
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S736
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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