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P01-16 - Similarity of the Neural Correlates of Neuroticism and Affective Measures, but not with Extraversion

Published online by Cambridge University Press:  17 April 2020

A. Brühl ,
M.-C. Viebke ,
T. Kaffenberger  and
U. Herwig
A. Brühl
Affiliation:
Clinic for Social and General Psychiatry, Psychiatric University Hospital Zürich, Zürich, Switzerland
M.-C. Viebke
Affiliation:
Clinic for Social and General Psychiatry, Psychiatric University Hospital Zürich, Zürich, Switzerland
T. Kaffenberger
Affiliation:
Clinic for Social and General Psychiatry, Psychiatric University Hospital Zürich, Zürich, Switzerland
U. Herwig
Affiliation:
Clinic for Social and General Psychiatry, Psychiatric University Hospital Zürich, Zürich, Switzerland Universitätsklinik für Psychiatrie und Psychotherapie III, Ulm, Germany

Abstract

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Objectives

Extraversion and neuroticism are differentially correlated with affective disorders: Neuroticism is strongly correlated with depression and anxiety disorders, whereas extraversion is rather negatively correlated with anxiety disorders. Theories have implicated a common biological basis of neuroticism and affective disorders.

Methods

This study examined neural correlates of neuroticism and extraversion as well as of affective measures with functional magnetic resonance imaging using a task addressing pessimistic emotion processing during the cued anticipation of emotional stimuli in 14 healthy subjects. The measures of personality and affectivity were used as primary covariates for the correlation with brain activity during the anticipation of emotional versus neutral stimuli to identify brain regions in which individual brain activity was strongly correlated with psychometric measures.

Results

Neuroticism, depression and anxiety were correlated with brain activity in parieto-temporo-occipital regions, functionally involved in visual-perceptual processing and attentional modulation, and also in caudate regions. Extraversion was correlated with brain activity particularly in prefrontal regions.

Conclusions

Our results point to possible common neural correlates of neuroticism and the affective measures, whereas extraversion seems to have a differential neurobiological basis. Particularly, the correlation with caudate regions, involved in implicit patterns of reaction, points to possible “automatized” biases in neuroticism and depression.

Type
Affective disorders / Unipolar depression / Bipolar disorder
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E235
Copyright
Copyright © European Psychiatric Association 2010
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