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Nucleus accumbens functional connectivity and circulating endocannabinoids levels in anorexia nervosa

Published online by Cambridge University Press:  01 September 2022

R. Miranda-Olivos ,
I. Baenas ,
A. Pastor ,
A. Del Pino ,
E. Codina ,
I. Sánchez ,
A. Juaneda-Segui ,
S. Jimenez-Murcia ,
R. De La Torre  and
C. Soriano-Mas
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R. Miranda-Olivos*
Affiliation:
Bellvitge University Hospital-IDIBELL, Psychiatry Department, Hospitalet del Llobregat, Spain Instituto Salud Carlos III, Ciber Fisiopatología Obesidad Y Nutrición (ciberobn), Madrid, Spain
I. Baenas
Affiliation:
Bellvitge University Hospital-IDIBELL, Psychiatry Department, Hospitalet del Llobregat, Spain Instituto Salud Carlos III, Ciber Fisiopatología Obesidad Y Nutrición (ciberobn), Madrid, Spain
A. Pastor
Affiliation:
IMIM-Hospital del Mar Research Institute, Integrated Pharmacology And Systems Neurosciences, BCN, Spain
A. Del Pino
Affiliation:
Bellvitge University Hospital-IDIBELL, Psychiatry Department, Hospitalet del Llobregat, Spain Department of Public Health, Mental Health and Perinatal Nursing, School of Nursing, University Of Barcelona, Hospitalet, Spain
E. Codina
Affiliation:
Bellvitge University Hospital-IDIBELL, Psychiatry Department, Hospitalet del Llobregat, Spain
I. Sánchez
Affiliation:
Bellvitge University Hospital-IDIBELL, Psychiatry Department, Hospitalet del Llobregat, Spain
A. Juaneda-Segui
Affiliation:
Bellvitge University Hospital-IDIBELL, Psychiatry Department, Hospitalet del Llobregat, Spain CIBERSAM, Instituto Salud Carlos Iii, Madrid, Spain
S. Jimenez-Murcia
Affiliation:
Bellvitge University Hospital-IDIBELL, Psychiatry Department, Hospitalet del Llobregat, Spain Instituto Salud Carlos III, Ciber Fisiopatología Obesidad Y Nutrición (ciberobn), Madrid, Spain University of Barcelona, Department Of Clinical Sciences, LHospitalet, Spain
R. De La Torre
Affiliation:
Instituto Salud Carlos III, Ciber Fisiopatología Obesidad Y Nutrición (ciberobn), Madrid, Spain Integrative Pharmacology and Systems Neuroscience, Hospital Del Mar Research Institute, BCN, Spain Universitat Pompeu Fabra, Department Of Experimental And Health Sciences, BCN, Spain
C. Soriano-Mas
Affiliation:
Bellvitge University Hospital-IDIBELL, Psychiatry Department, Hospitalet del Llobregat, Spain Instituto Salud Carlos III, Ciber Salud Mental (cibersam), Madrid, Spain Universitat Autònoma de Barcelona, Departament De Psicobiologia I Metodologia De Les Ciències De La Salut, BCN, Spain
F. Fernandez-Aranda
Affiliation:
Bellvitge University Hospital-IDIBELL, Psychiatry Department, Hospitalet del Llobregat, Spain Instituto Salud Carlos III, Ciber Fisiopatología Obesidad Y Nutrición (ciberobn), Madrid, Spain School of Medicine and Health Sciences, University of Barcelona, Department Of Clinical Sciences, Barcelona -Campus Bellvitge, Spain
*
*Corresponding author.

Abstract

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Introduction

Neuroimaging findings have reported aberrant functional connectivity in brain regions involved reward system in individuals with anorexia nervosa (AN) altering hedonic processing over food. Likewise, endocannabinoids such as Anandamide (AEA) and 2-Arachidonoylglycerol (2-AG) have been involved in rewarding aspects of food intake.

Objectives

To identify nucleus accumbens (NAcc) functional connectivity with whole-brain comparing between individuals with AN and controls. Furthermore, in a sub-study, to explore the interaction between NAcc functional connectivity and peripheral AEA and 2-AG levels.

Methods

A total of 60 adult women (18 to 56 years of age) took part in the present study. Twenty-six individuals belonged to the AN group (BMI<18) and 34 to the HC group (BMI=18-24.99). All participants underwent functional magnetic resonance in resting-state, and blood samples were obtained in fasting.

Results

Negative functional connectivity was observed in the AN group compared with the control group between the NAcc and the cerebellum (pFWE<.001), between the NAcc and the insula (pFWE<.001), between the NAcc and the supramarginal gyrus (pFWE=.019), and between the NAcc and the postcentral gyrus (pFWE=.010). Analyses exploring the association between NAcc functional connectivity and peripheral endocannabinoids levels displayed altered NAcc-cerebellum functional connectivity was negatively associated with peripheral 2-AG levels in the AN group (r= -.553; p=.011).

Conclusions

Understanding the interaction between the reward system and peripheral endocannabinoids in patients with AN could contribute to better elucidate the pathophysiology of this disorder. Future studies will need to further investigate the clinical and therapeutic implications of these findings in patients with AN.

Disclosure

No significant relationships.

Keywords

nucleus accumbensEndocannabinoidsresting-state functional connectivityAnorexia nervosa
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S90 - S91
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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