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Hyperbaric oxygenation of autoimmune manifestation in coversational disorders

Published online by Cambridge University Press:  13 August 2021

D. Labunskiy ,
S. Kiryukhina ,
V. Podsevatkin ,
E. Govsh  and
V. Kolmyykov
D. Labunskiy*
Affiliation:
Neurology And Psychiatry, Ogarev Mordovia State University, Saransk, Russian Federation
S. Kiryukhina
Affiliation:
Neurology And Psychiatry, Ogarev Mordovia State University, Saransk, Russian Federation
V. Podsevatkin
Affiliation:
Neurology And Psychiatry, Ogarev Mordovia State University, Saransk, Russian Federation
E. Govsh
Affiliation:
Neurology And Psychiatry, Ogarev Mordovia State University, Saransk, Russian Federation
V. Kolmyykov
Affiliation:
Neurology And Psychiatry, Ogarev Mordovia State University, Saransk, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Study of conversion disorders is urgent problem in psychiatry due to high prevalence of hysterical manifestations, both in structure of various mental diseases and in general somatic network: among population it is from 0.5 to 2%.

Objectives

Our aim was to study the effect of complex therapy, combining traditional psychopharmacological drugs and hyperbaric oxygenation, on indicators of acid-base balance of blood, neurotransmitter metabolism, immune and hormonal status in experimental modeling of stress, as well as reduction of psychopathological symptoms in various forms of hysterical disorders.

Methods

Studies were conducted with the participation of 160 patients (145 women and 15 men), average age 33.5 ± 6.1 years, Сontent of adrenaline, norepinephrine, dopamine, serotonin was determined by concentration of prolactin, thyroid-stimulating hormone (TSH), free thyroxine (T4 light), cortisol using ELISA. Immune status was assessed according to following indicators: determination of level of immunoglobulins of classes A, M and G by the method of radial immunodiffusion in a gel; study of total complementary activity of blood serum by hemolytic method.

Results

It is necessary to highlight a significant increase in the concentration of Ig G and Ig A, a higher level of large, medium and small circulating immune complexes, which does not exclude the development of autoimmune reactions as a result of a long course of the mental process, which occurs with damage to the own cells of the nervous tissue.

Conclusions

Кevealed changes in the immune and endocrine reactions upon admission, under the influence of HBO treatment indicate involvement of these structures in the pathogenetic mechanisms.

Disclosure

No significant relationships.

Keywords

Conversional DisordersHyperbaric OxygenaationsImmunoglobulins
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S147 - S148
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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