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Brain Abnormalities and Outcome in People with Schizophrenia – Recent Findings

Published online by Cambridge University Press:  15 April 2020

A. Heinz
Affiliation:
Department of Psychiatry and Psychotherapy, Charité – University Medicine Berlin, Berlin, Germany
C. Hägele
Affiliation:
Department of Psychiatry and Psychotherapy, Charité – University Medicine Berlin, Berlin, Germany
S. Weinmann
Affiliation:
Institute for Social Medicine Epidemiology and Health Economics, Charité – University Medicine Berlin, Berlin, Germany
V. Aderhold
Affiliation:
Department of Psychiatry and Psychotherapy, University Clinic Hamburg, Hamburg, Germany

Abstract

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Antipsychotic medication can substantially improve acute psychotic symptoms, however, there is an increasing concern about long-term effects of anti-psychotic medication. We review brain imaging studies that assess prefrontal cortical volume in longitudinal designs and report the effects of neuroleptic dose as well as symptom severity. In these prospective studies, a majority of studies reported a significant effect of neuroleptic dose on brain volume reductions when controlling for symptom severity. These findings strengthen the concern that long-term and rather high dose neuroleptic medication contribute to prefrontal cortical atrophy. Low doses and psychosocial and psychotherapeutic interventions that help to reduce the need for medication therefore are highly warranted.

Type
Article: 0064
Copyright
Copyright © European Psychiatric Association 2015
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