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An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population

Published online by Cambridge University Press:  16 April 2020

Yanbin Jia ,
Xin Yu ,
Boyu Zhang ,
Yanbo Yuan ,
Qi Xu ,
Yucun Shen  and
Yan Shen
Yanbin Jia
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, 100005, China National Center of Human Genome Research, Beijing, 100176, China
Xin Yu
Affiliation:
Peking University Institute of Mental Health, Beijing, 100083, China
Boyu Zhang
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, 100005, China National Center of Human Genome Research, Beijing, 100176, China
Yanbo Yuan
Affiliation:
Peking University Institute of Mental Health, Beijing, 100083, China
Qi Xu
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, 100005, China National Center of Human Genome Research, Beijing, 100176, China
Yucun Shen
Affiliation:
Peking University Institute of Mental Health, Beijing, 100083, China
Yan Shen*
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, 100005, China National Center of Human Genome Research, Beijing, 100176, China
*
* Corresponding author. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS & PUMC, 5, Dong Dan San Tiao, Beijing, 100005, China. Email address: [email protected] (Y. Shen).
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Abstract

We performed an association study between three SNPs in the genes of 14-3-3 family and paranoid schizophrenia. SNP rs983583 G/A in the YWHAZ gene showed significant association with paranoid schizophrenia. Our study indicated that the YWHAZ gene was a potential susceptibility gene for paranoid schizophrenia in the population studied.

Keywords

YWHABYWHAGYWHAZSNP
Type
Rapid communication
Information
European Psychiatry , Volume 19 , Issue 6 , September 2004 , pp. 377 - 379
Copyright
Copyright © 2004 European Psychiatric Association

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Footnotes

1

These authors contributed equally to this work.

References

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