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Psychiatric neuroimaging: Joining forces with epidemiology

Published online by Cambridge University Press:  16 April 2020

David Glahn ,
Abraham Reichenberg ,
Sophia Frangou  and
Hans Ormel
David Glahn
Affiliation:
Department of Psychiatry and Research Imaging Center, University of Texas Health Science Center at San Antonio, TX, USA
Abraham Reichenberg*
Affiliation:
Section of Cognitive Neuropsychiatry, Institute of Psychiatry, Kings College London, London, UK
Sophia Frangou
Affiliation:
Section of Neurobiology of Psychosis, Institute of Psychiatry, Kings College London, London, UK
Hans Ormel
Affiliation:
Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands
*
∗Corresponding author. Tel.: +44 20 7848 5241. E-mail address: [email protected] (A. Reichenberg).
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Abstract

Severe mental illnesses such as schizophrenia and mood disorders have a major impact on public health. Disease prevalence and phenotypic expression are the products of environment and gene interactions. However, our incomplete understanding of their aetiology and pathophysiology thwarts primary prevention and early diagnosis and limits the effective application of currently available treatments as well as the development of novel therapeutic approaches. Neuroimaging can provide detailed in vivo information about the biological mechanisms underpinning the relationship between genetic variation and clinical phenotypes or response to treatment. However, the biological complexity of severe mental illness results from unknown or unpredictable interactions between multiple genetic and environmental factors, many of which have only been partially identified. We propose that the use of epidemiological principles to neuroimaging research is a necessary next step in psychiatric research. Because of the complexity of mental disorders and the multiple risk factors involved only the use of large epidemiologically defined samples will allow us to study the broader spectrum of psychopathology, including sub-threshold presentation and explore pathophysiological processes and the functional impact of genetic and non-genetic factors on the onset and persistence of psychopathology.

Keywords

PsychosisSchizophreniaBipolar disorderRisk factors
Type
Original article
Information
European Psychiatry , Volume 23 , Issue 4 , June 2008 , pp. 315 - 319
Copyright
Copyright © European Psychiatric Association 2008

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References

Arseneault, L.Cannon, M.Poulton, R.Murray, R.Caspi, A.Moffitt, T.E.Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study. BMJ 2002;325:1212–1213.CrossRefGoogle ScholarPubMed
Brown, A.S.Begg, M.D.Gravenstein, S.Schaefer, C.A.Wyatt, R.J.Bresnahan, M.et al.Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry 2004;61:774–780.CrossRefGoogle ScholarPubMed
Cannon, M.Jones, P.B.Murray, R.M.Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry 2002;159:1080–1092.CrossRefGoogle ScholarPubMed
Cannon, T.D.Clinical and genetic high-risk strategies in understanding vulnerability to psychosis. Schizophr Res 2005;79:35–44.CrossRefGoogle ScholarPubMed
Caspi, A.Moffitt, T.E.Cannon, M.McClay, J.Murray, R.Harrington, H.et al.Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. Biol Psychiatry 2005;57:1117–1127.CrossRefGoogle ScholarPubMed
Chang, L.Yakupov, R.Cloak, C.Ernst, T.Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation. Brain 2006;129(Pt 5):1096–1112.CrossRefGoogle ScholarPubMed
Darwin, C.R.The effects of cross and self-fertilisation in the vegetable kingdom. London: John Murray; 1876.CrossRefGoogle Scholar
Davidson, M.Reichenberg, A.Rabinowitz, J.Weiser, M.Kaplan, Z.Mark, M.Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents. Am J Psychiatry 1999;156:1328–1335.Google ScholarPubMed
Earls, F.Epidemiology and child psychiatry: entering the second phase. Am J Orthopsychiatry 1989;59:279–283.CrossRefGoogle ScholarPubMed
Fombonne, E.Epidemiology of autistic disorder and other pervasive developmental disorders. J Clin Psychiatry 2005;66(Suppl. 10):3–8.Google ScholarPubMed
Fu, C.H.Williams, S.C.Cleare, A.J.Brammer, M.J.Walsh, N.D.Kim, J.et al.Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. Arch Gen Psychiatry 2004;61:877–889.CrossRefGoogle ScholarPubMed
Hariri, A.R.Mattay, V.S.Tessitore, A.Kolachana, B.Fera, F.Goldman, D.et al.Serotonin transporter genetic variation and the response of the human amygdala. Science 2002;297:400–403.CrossRefGoogle ScholarPubMed
Hariri, A.R.Weinberger, D.R.Functional neuroimaging of genetic variation in serotonergic neurotransmission. Genes Brain Behav 2003;2:341–349.CrossRefGoogle ScholarPubMed
Harrison, P.J.Weinberger, D.R.Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 2005;10:40–68.CrossRefGoogle ScholarPubMed
Honey, G.D.Bullmore, E.T.Soni, W.Varatheesan, M.Williams, S.C.Sharma, T.Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical antipsychotic drugs in patients with schizophrenia. Proc Natl Acad Sci U S A 1999;96:13432–13437.CrossRefGoogle ScholarPubMed
Jager, G.Kahn, R.S.Van Den Brink, W.Van Ree, J.M.Ramsey, N.F.Long-term effects of frequent cannabis use on working memory and attention: an fMRI study. Psychopharmacology (Berl) 2006;185:358–368.CrossRefGoogle ScholarPubMed
Jager, G.Van Hell, H.H.De Win, M.M.Kahn, R.S.Van Den Brink, W.Van Ree, J.M.et al.Effects of frequent cannabis use on hippocampal activity during an associative memory task. Eur Neuropsychopharmacol 2007;17:289–297.CrossRefGoogle ScholarPubMed
Jones, P.Rodgers, B.Murray, R.Marmot, M.Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet 1994;344:1398–1402.CrossRefGoogle ScholarPubMed
Kendler, K.S.Davis, C.G.Kessler, R.C.The familial aggregation of common psychiatric and substance use disorders in the National Comorbidity Survey: a family history study. Br J Psychiatry 1997;170:541–548.CrossRefGoogle ScholarPubMed
Kendler, K.S.Neale, M.C.Walsh, D.Evaluating the spectrum concept of schizophrenia in the Roscommon Family Study. Am J Psychiatry 1995;152:749–754.Google ScholarPubMed
Kessler, R.C.Walters, E.E.Epidemiology of DSM-III-R major depression and minor depression among adolescents and young adults in the National Comorbidity Survey. Depress Anxiety 1998;7(1):3–14.3.0.CO;2-F>CrossRefGoogle Scholar
King, M.Coker, E.Leavey, G.Hoare, A.Johnson-Sabine, E.Incidence of psychotic illness in London: comparison of ethnic groups. BMJ 1994;309:1115–1119.CrossRefGoogle ScholarPubMed
Liddle, P.F.Friston, K.J.Frith, C.D.Hirsch, S.R.Jones, T.Frackowiak, R.S.Patterns of cerebral blood flow in schizophrenia. Br J Psychiatry 1992;160:179–186.CrossRefGoogle Scholar
Lopez, A.D.Murray, C.C.The global burden of disease, 1990–2020. Nat Med 1998;4:1241–1243.CrossRefGoogle ScholarPubMed
Mayberg, H.S.Brannan, S.K.Mahurin, R.K.Jerabek, P.A.Brickman, J.S.Tekell, J.L.et al.Cingulate function in depression: a potential predictor of treatment response. Neuroreport 1997;8:1057–1061.CrossRefGoogle Scholar
McGuire, P.K.Shah, G.M.S.Murray, R.M.Increased blood flow in Broca's area during auditory hallucinations in schizophrenia. Lancet 1993;342:703–706.CrossRefGoogle Scholar
van Os, J.Pedersen, C.B.Mortensen, P.B.Confirmation of synergy between urbanicity and familial liability in the causation of psychosis. Am J Psychiatry 2004;161:2312–2314.CrossRefGoogle Scholar
Reichenberg, A.Weiser, M.Rabinowitz, J.Caspi, A.Schmeidler, J.Mark, M.et al.A population-based cohort study of premorbid intellectual, language, and behavioral functioning in patients with schizophrenia, schizoaffective disorder, and nonpsychotic bipolar disorder. Am J Psychiatry 2002;159:2027–2035.CrossRefGoogle ScholarPubMed
Reiss, A.L.Dant, C.C.The behavioral neurogenetics of fragile X syndrome: analyzing gene–brain–behavior relationships in child developmental psychopathologies. Dev Psychopathol 2003;15:927–968.CrossRefGoogle ScholarPubMed
Shergill, S.S.Brammer, M.J.Williams, S.C.Murray, R.M.McGuire, P.K.Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging. Arch Gen Psychiatry 2000;57:1033–1038.CrossRefGoogle ScholarPubMed
Slattery, D.A.Hudson, A.L.Nutt, D.J.Invited review: the evolution of antidepressant mechanisms. Fundam Clin Pharmacol 2004;18:1–21.CrossRefGoogle ScholarPubMed
Szatmari, P.White, J.Merikangas, K.R.The use of genetic epidemiology to guide classification in child and adult psychopathology. Int Rev Psychiatry 2007;19:483–496.CrossRefGoogle ScholarPubMed
Weinberger, D.R.Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987;44:660–669.CrossRefGoogle ScholarPubMed
Zammit, S.Allebeck, P.David, A.S.Dalman, C.Hemmingsson, T.Lundberg, I.et al.A longitudinal study of premorbid IQ Score and risk of developing schizophrenia, bipolar disorder, severe depression, and other nonaffective psychoses. Arch Gen Psychiatry 2004;61:354–360.CrossRefGoogle ScholarPubMed
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