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Platelet monoamine oxidase activity in obsessive-compulsive disorder

Published online by Cambridge University Press:  16 April 2020

Manuel Arrojo ,
Enrique Baca-Garcia ,
Maria Mercedes Perez-Rodriguez ,
Helen Dolengevich-Segal ,
Mercedes Navio-Acosta ,
Beatriz Rodriguez-Salgado  and
Jeronimo Saiz-Ruiz
Manuel Arrojo
Affiliation:
Department of Psychiatry, Ramon y Cajal Hospital, Carretera de Colmenar Viejo km 9.1, 28034Madrid, Spain
Enrique Baca-Garcia*
Affiliation:
Department of Neurosciences, Columbia University Medical Center, 1051 Riverside Drive, Suite 2917/Unit 42, New York, NY10032, USA Department of Psychiatry, Fundacion Jimenez Diaz, Avenida Reyes Catolicos 2, 28040Madrid, Spain Department of Psychiatry, Faculty of Medicine, Autonoma University of Madrid, Calle Arzobispo Morcillo, 28029Madrid, Spain
Maria Mercedes Perez-Rodriguez
Affiliation:
Department of Psychiatry, Ramon y Cajal Hospital, Carretera de Colmenar Viejo km 9.1, 28034Madrid, Spain
Helen Dolengevich-Segal
Affiliation:
Department of Psychiatry, Ramon y Cajal Hospital, Carretera de Colmenar Viejo km 9.1, 28034Madrid, Spain
Mercedes Navio-Acosta
Affiliation:
Department of Psychiatry, Ramon y Cajal Hospital, Carretera de Colmenar Viejo km 9.1, 28034Madrid, Spain
Beatriz Rodriguez-Salgado
Affiliation:
Department of Psychiatry, Ramon y Cajal Hospital, Carretera de Colmenar Viejo km 9.1, 28034Madrid, Spain
Jeronimo Saiz-Ruiz
Affiliation:
Department of Psychiatry, Ramon y Cajal Hospital, Carretera de Colmenar Viejo km 9.1, 28034Madrid, Spain University of Alcala, Madrid, Spain
*
*Corresponding author. Department of Neurosciences, Columbia University Medical Center, 1051 Riverside Drive, Suite 2917/Unit 42, New York, NY 10032, USA. Tel.: +1 212 543 6544; fax: +1 212 543 6017. E-mail addresses: [email protected] (M. Arrojo), [email protected] (E. Baca-Garcia), [email protected] (M.M. Perez-Rodriguez), [email protected] (H. Dolengevich-Segal), [email protected] (M. Navio-Acosta), [email protected] (B. Rodriguez-Salgado), jsaiz.hrc@ salud.madrid.org (J. Saiz-Ruiz).
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Abstract

Response to SSRIs suggests the implication of the serotonergic system in obsessive-compulsive disorder (OCD). However, biological studies on serotonergic function in OCD have yielded contradictory results. Platelet monoamine oxidase (MAO) activity has been proposed as an index of cerebral serotonin activity.

The aim of this study was to examine platelet MAO activity in 29 OCD patients and 29 healthy controls matched by age, sex and tobacco use. We also explored the relationship between platelet MAO activity and aggressive obsessions in OCD patients.

There were no differences in platelet MAO activity between OCD patients and healthy controls. We found a significant correlation between platelet MAO activity and Y-BOCS scores in the group of patients with Y-BOCS scores >15.

OCD patients with aggressive obsessions had significantly lower levels of platelet MAO activity than patients without aggressive obsessions.

Our results suggest that platelet MAO activity may be a marker of OCD severity, and that low platelet MAO activity may be associated with aggressive obsessions in OCD patients.

Keywords

Obsessive-compulsive disorderPlatelet MAO activitySerotoninAggression
Type
Original article
Information
European Psychiatry , Volume 22 , Issue 8 , November 2007 , pp. 525 - 529
Copyright
Copyright © Elsevier Masson SAS 2007

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