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Long-term outcomes in patients with schizophrenia treated with risperidone long-acting injection or oral antipsychotics in Spain: Results from the electronic Schizophrenia Treatment Adherence Registry (e-STAR)

Published online by Cambridge University Press:  16 April 2020

J.M. Olivares ,
A. Rodriguez-Morales ,
J. Diels ,
M. Povey ,
A. Jacobs ,
Z. Zhao  and
A. Lam
J.M. Olivares*
Affiliation:
Department of Psychiatry, Hospital Meixoeiro, Complejo Hospitalario Universitario de Vigo, VigoSpain
A. Rodriguez-Morales
Affiliation:
Janssen Cilag, Spain
J. Diels
Affiliation:
Janssen Pharmaceutica, Beerse, Belgium
M. Povey
Affiliation:
SGS Biopharma, Wavre, Belgium
A. Jacobs
Affiliation:
Johnson and Johnson Pharmaceutical Services, Raritan, NJ, USA
Z. Zhao
Affiliation:
Johnson and Johnson Pharmaceutical Services, Raritan, NJ, USA
A. Lam
Affiliation:
Johnson and Johnson Pharmaceutical Services, Raritan, NJ, USA
*
*Corresponding author. Servicio de Psiquiatria, Hospital Meixoeiro, Complejo Hospitalario Universitario de Vigo, 36200, Spain. Tel.: +34 986811100; fax: +34 986811138. E-mail address: [email protected]
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Abstract

Background

The electronic Schizophrenia Treatment Adherence Registry (e-STAR) is a prospective, observational study of patients with schizophrenia designed to evaluate long-term treatment outcomes in routine clinical practice.

Methods

Parameters were assessed at baseline and at 3 month intervals for 2 years in patients initiated on risperidone long-acting injection (RLAI) (n = 1345) or a new oral antipsychotic (AP) (n = 277; 35.7% and 36.5% on risperidone and olanzapine, respectively) in Spain. Hospitalization prior to therapy was assessed by a retrospective chart review.

Results

At 24 months, treatment retention (81.8% for RLAI versus 63.4% for oral APs, p < 0.0001) and reduction in Clinical Global Impression Severity scores (−1.14 for RLAI versus −0.94 for APs, p = 0.0165) were significantly higher with RLAI. Compared to the pre-switch period, RLAI patients had greater reductions in the number (reduction of 0.37 stays per patient versus 0.2, p < 0.05) and days (18.74 versus 13.02, p < 0.01) of hospitalizations at 24 months than oral AP patients.

Conclusions

This 2 year, prospective, observational study showed that, compared to oral antipsychotics, RLAI was associated with better treatment retention, greater improvement in clinical symptoms and functioning, and greater reduction in hospital stays and days in hospital in patients with schizophrenia. Improved treatment adherence, increased efficacy and reduced hospitalization with RLAI offer the opportunity of substantial therapeutic improvement in schizophrenia.

Keywords

Risperidone long-acting injectionAntipsychotic medicationSchizophreniaTreatment retentionObservational study
Type
Original article
Information
European Psychiatry , Volume 24 , Issue 5 , June 2009 , pp. 287 - 296
Copyright
Copyright © Elsevier Masson SAS 2009

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Footnotes

1

On behalf of the e-STAR study group.

*

Parts of this study have been presented at the Association of European Psychiatrists 16th European Congress of Psychiatry, April 5—9, 2008, Nice, France, and the American Psychiatric Association's 161st annual meeting, May 3—8, 2008, Washington DC, USA.

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