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Genetic vulnerability to drug abuse

Published online by Cambridge University Press:  16 April 2020

E. Duaux ,
M.O. Krebs ,
H. Loo  and
M.F. Poirier
E. Duaux
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et Thérapeutique, Hôpital Sainte-Anne, 75014, Paris, France
M.O. Krebs
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et Thérapeutique, Hôpital Sainte-Anne, 75014, Paris, France
H. Loo
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et Thérapeutique, Hôpital Sainte-Anne, 75014, Paris, France
M.F. Poirier
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et Thérapeutique, Hôpital Sainte-Anne, 75014, Paris, France
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Summary

Addiction to various substances, including drugs and alcohol, probably arises from a combination of environmental and genetic factors. The genetic vulnerability to drug addiction is supported by several familial, adoption and twin studies. However, as in other mental disorders, the genetic vulnerability to drug addiction appears complex: these disorders do not follow the rules of Mendelian inheritance. Instead, they are probably influenced by multiple susceptibility genes, each of which contributes to the disorder. The more genes necessary for a disorder, the harder it is to detect any of them. This difficulty is magnified by the role of environmental factors. Association studies using the candidate gene approach can identify susceptibility genes for drug abuse supported by the pathophysiological hypothesis of the illness. This review will focus on the clinical and molecular genetic studies in drug abuse.

Keywords

addictionalleleassociationdrug abusegeneticspolymorphism
Type
Original Article
Information
European Psychiatry , Volume 15 , Issue 2 , March 2000 , pp. 109 - 114
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2000

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