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Are genes coding for dopamine receptors implicated in alcoholism?

Published online by Cambridge University Press:  16 April 2020

P Gorwood ,
J Ades  and
J Feingold
P Gorwood
Affiliation:
Unité de recherches d’épidémiologie génétique, INSERM Unité 155, Université Paris VII - Tour 16, 2, place Jussieu, 75005, Paris Hôpital Louis-Mourier, 178, rue des Renouillers, 92701Colombes, France
J Ades
Affiliation:
Hôpital Louis-Mourier, 178, rue des Renouillers, 92701Colombes, France
J Feingold
Affiliation:
Unité de recherches d’épidémiologie génétique, INSERM Unité 155, Université Paris VII - Tour 16, 2, place Jussieu, 75005, Paris
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Summary

Part of the familial factor of alcoholism is associated with the existence of genetic vulnerability. Genetic factors which interact with the pathogenesis of alcoholism are nevertheless complex, partial and for the moment partly unknown at the biological level. Recently, many association studies have been published concerning alcohol-dependence and genes coding for the second dopamine receptor. These associations, which have had positive replications, raise many questions. First of all, should the inheritance of alcoholism be regarded as a definitive fact? Secondly what is inherited? It could be alcoholism in general, a component of this disease (for instance, dependence on, sensitivity to or the seeking-process for alcohol), a specific pattern of drinking, presence of complications linked to alcohol abuse, or more general features, common to many addiction diseases. Thirdly, how could dopamine be linked to alcoholism? Furthermore, how should these positive associations be considered, given that two of these studies were negative, and that all linkage studies were negative. Lastly, are there other clues and ways of finding genetic vulnerability factors for alcohol abuse?

Keywords

alcoholismalcohol-dependencegeneticsdopamine
Type
Special article
Information
European Psychiatry , Volume 9 , Issue 2 , 1994 , pp. 63 - 69
Copyright
Copyright © European Psychiatric Association 1994

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References

Aston, CEHill, SY. Segregation analysis of alcoholism in families ascertained through a pair of male alcoholics. Am J Hum Genet 1990;46:879-87Google ScholarPubMed
Blackburn, JRPhillips, AGFibiger, HC. Dopamine and preparatory behaviour: I. Effects of pimozide. Behav Neurosci 1987;101:352-60CrossRefGoogle ScholarPubMed
Blackburn, JRPhillips, AGJakubovic, AFibiger, HC. Dopamine and preparatory behaviour: II. A neurochemical analysis. Behav Neurosci 1989;103:15–23CrossRefGoogle Scholar
Bohman, M. Some genetic aspects of alcoholism and criminality: A population of adoptees. Arch Gen Psychiatry 1978;35:269-76CrossRefGoogle ScholarPubMed
Bohman, MSigvardsson, SCloninger, R. Maternal inheritance of alcohol abuse. Cross-fostering analysis of adopted women. Arch Gen Psychiatry 1981;38:965-69CrossRefGoogle ScholarPubMed
Bolos, AMDean, MDLucs-Derse, SRamsburg, MBrown, GLGoldman, D. Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene and alcoholism. JAMA 1990;264:3156-60CrossRefGoogle ScholarPubMed
Blum, KNoble, EPSheridan, PJ. Allelic association of human dopamine D2 receptor gene and alcoholism. JAMA 1990;263:2055-60CrossRefGoogle ScholarPubMed
Cadoret, RJGath, A. Inheritance of alcoholism in adoptees. Br J Psychiatry 1978;132:252-8CrossRefGoogle Scholar
Cloninger, CRChristiansen, KOReich, TGottesman, II. Implications of sex differences in the prevalences of antisocial personality, alcoholism, and criminality for familial transmission. Arch Gen Psychiatry 1978;35:941-51CrossRefGoogle ScholarPubMed
Cloninger, CR. Neurogenetic adaptive mechanisms in alcoholism. Science 1987;236:410-6CrossRefGoogle ScholarPubMed
Cloninger, CR. D2 dopamine receptor gene is associated but not linked with alcoholism. JAMA 1991;266:1833-4CrossRefGoogle Scholar
Comings, DEComings, BGMuhleman, Det al. The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA 1991;266:1793–1800CrossRefGoogle ScholarPubMed
Cotton, NS. The familial incidence of alcoholism. J Stud Alcohol 1979;40:89–116CrossRefGoogle ScholarPubMed
Di Chiarra, GImperato, A. Drugs abused by humans preferentially increase synaptic dopamine concentration in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 1988;85:5274-8CrossRefGoogle Scholar
Gelertner, JO'Malley, SRisch, N. No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism. JAMA 1991;266:1801-7Google Scholar
Gessa, GLMuntoni, GCollu, MVargiu, LMereu, G. Low doses of ethanol activate dopaminergic neurones in the ventral tegmental area. Brain Res 1985;348:201CrossRefGoogle Scholar
George, FR. Genetic approaches to studying drug abuse: correlates of drug self-administration. Alcohol 1990;7:207-11CrossRefGoogle ScholarPubMed
Gilligan, SBReich, TCloninger, CR. Etiologic heterogeneity in alcoholism. Genet Epidemiol 1987;4:395–414CrossRefGoogle ScholarPubMed
Goodwin, DWSchulsinger, FMoller, Net al. Drinking problems in adopted and nonadopted sons of alcoholics. Arch Gen Psychiatry 1974;31:164-9CrossRefGoogle Scholar
Grandy, DKMarchionni, MAMakam, H. Cloning of the cDNA and gene for the human D2 dopamine receptor. Proc Natl Acad Sci USA 1989;86:9762-6CrossRefGoogle ScholarPubMed
Hauge, XYGrandy, DKEubanks, JH. Evans, GA. Civelli, O. Litt, M. Detection and characterisation of additional DNA polymorphisms in the dopamine D2 receptor gene. Genomics 1991;10:527-30CrossRefGoogle Scholar
Heath, RG. The Role of Pleasure in Behaviour. New York: Harper & Row, 1964Google Scholar
Hrubec, ZOmenn, GS. Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: twin concordances for alcoholism and its biological end points by zygoty among male veterans. Alcohol Clin Exp Res 1981;5:207-15CrossRefGoogle Scholar
Iversen, SD. In: Iversen, LLIversen, SDSnyder, SH eds. Handbook of Psychopharmacology. New York: Plenum, 1977;8:333-74CrossRefGoogle Scholar
Kaij, L. Alcoholism in Twins. Stockholm: Almqvist & Wiksell, 1960Google Scholar
Kalant, H. Tolerance, learning and neurochemical adaptation. Can J Physiol Pharmacol 1985;63:1485-94CrossRefGoogle ScholarPubMed
Kelley, AStinus, L. In: Fox, NADavidson, RJ eds. Affective Development: A Psychobiological Perspective. Erbaulm: Hillsdale, NY, 1984;1–75Google Scholar
Khanna, JMKalant, HLê, ADLeBlanc, AE. Role of serotonin (5-HT) in drug tolerance and general adaptation. Acta Psychiatrica Scand (suppl) 1980;286:161CrossRefGoogle ScholarPubMed
Kiianmaa, KTabakoff, B. Neurochemical correlates of tolerance and strain differences in the neurochemical effects of ethanol. Pharmacol Biochem Behav 1983;18 (suppl 1):383-88CrossRefGoogle ScholarPubMed
Koob, GFDopamine, addiction and reward. Neurosci 1992;4:139-48Google Scholar
Lippa, ASAntelman, SMFisher, AECanfield, RD. Neurochemical mediation of reward: a significant role of dopamine? Pharmacol Biochem Behav 1973;1:23-8CrossRefGoogle ScholarPubMed
Melchior, CLTabakoff, B. Modification of environmentally cued tolerance to ethanol in mice. J Pharmacol Exp Ther 1981;219: 175-80Google ScholarPubMed
Murphey, JMMcBride, WJLumeng, LLi, TK. Monoamine and metabolite levels in CNS regions of the P line of alcohol-preferring rats after acute and chronic ethanol treatment. Pharmacol Biochem Behav 1983;19:849-56CrossRefGoogle Scholar
Murray, RMGurlin, CC. Twin and alcoholism studies.In: Galanter, M ed. Recent Developments in Alcoholism. New York: Gardner Press, 1983;1Google Scholar
Nichols, JR. The children of addicts: what do they inherit? Ann NY Acad Sci 1972;197:60-5CrossRefGoogle ScholarPubMed
Parsian, ATodd, RDevor, EO'Malley, KSuarez, BReich, TCloninger, R. Alcoholism and alleles of the human D2 dopamine receptor locus. Arch Gen Psychiatry 1991;48:655-63CrossRefGoogle ScholarPubMed
Penick, ECRead, MRCrowley, PA. Differentiation of alcoholics by family history. J Stud Alcohol 1978;39:1944-8CrossRefGoogle ScholarPubMed
Pfaus, JGDamsma, GNomikos, GGWeikstern, DJBlaha, CDPhillips, AGFibiger, HC. Sexual behaviour enhances central dopamine transmission in the male rat. Brain Res 1990;530:345-8CrossRefGoogle ScholarPubMed
Phillips, TJFeller, DJCrabbe, JC. Selected mouse lines, alcohol and behaviour. Experientia 1989;45:805-27CrossRefGoogle Scholar
Propping, P. Alcohol and alcoholism. Hum Genet 1978;35:309-34CrossRefGoogle Scholar
Ritz, MCLamb, RJGoldberg, SRKuhar, MJ. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 1987;237:1219-23CrossRefGoogle ScholarPubMed
Routtenberg, A. The reward system of the brain. Sci Am 1978;239:122-31CrossRefGoogle Scholar
Schuckit, MA. Alcoholic men with no first-degree relatives. Am J Psychiatry 1983;140:439-43Google ScholarPubMed
Schwartz, JCGiros, BMartres, MPSokoloff, P. The dopamine receptor family: molecular biology and pharmacology. Neurosci 1992;4Google Scholar
Smith, SSO'Hara, BFPersico, AMet al. The D2 dopamine taq B1 RFLP appears more frequently in polysubstance abusers. Arch Gen Psychiatry 1992;49:723-7CrossRefGoogle ScholarPubMed
Stellar, JRStellar, E. The Neurobiology of Motivation and Reward. New York: Springer-Verlag, 1985CrossRefGoogle Scholar
Tabakoff, BRitzman, RF. Acute tolerance in inbred and selected lines of mice. Drug Alcohol Depend 1979;4:87–90CrossRefGoogle Scholar
Uhl, GRPersico, AMSmith, SS. Current excitement with dopamine receptor gene alleles in substance abuse. Arch Gen Psychiatry 1992;49:157-60CrossRefGoogle ScholarPubMed
Waler, MBMurphy, JMMcBride, WJLumeng, LLi, TK. Pharmacol Biochem Behav 1986;24:617CrossRefGoogle Scholar
Warner, RRossett, H. The effect of drinking on offspring: an historical review of the American and British literature. J Stud Alcohol 1975;36:1395-20CrossRefGoogle Scholar
Weiss, FHurd, YUngerstedt, UMarkou, APlosky, PKoob, GF. Neurochemical correlates of cocaine and ethanol self-administration. NY Acad Sci USA 1992CrossRefGoogle ScholarPubMed
Wise, RARompre, PP. Brain dopamine and reward. Ann Rev Psychol 1989;40:191–225CrossRefGoogle ScholarPubMed
Wise, RA. Action of drugs of abuse on brain reward systems. Pharmacol Biochem Behav (suppl) 1980;13:213-33CrossRefGoogle ScholarPubMed
Woolf, B. On estimating the relation between blood group and disease. Ann Hum Genet 1955;19:251-3CrossRefGoogle Scholar
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