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Abnormal auditory N400 in a case of zolpidem dependence, during a working memory test

Published online by Cambridge University Press:  16 April 2020

Ioannis A. Liappas ,
Charalabos C. Papageorgiou  and
Andreas D. Rabavilas
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Abstract

Zolpidem is a GABA (A) agonist, which is indicated for the short-term management of insomnia. Recent research provide evidence suggesting that zolpidem produces spatial working memory (WM) deficits and dependence; however, the underlying mechanisms of these effects are unknown. Since the auditory N400 component of event-related potentials (ERPS) is considered as an index of memory use of context processing, the present study focused on N400 waveform of ERPs elicited during a WM task in a case suffering from zolpidem dependence. The patterns of N400 waveform of this case were compared to the patterns obtained from healthy controls. This comparison revealed that zolpidem dependence is accompanied by reduced amplitudes located at posterior brain areas and diffuse prolongation of N400. These findings may indicate that zolpidem dependence manifests alterations with regard to the memory use of context processing, involving or affecting a wide-ranging network of the brain's structures.

Keywords

Auditory N400DependenceEvent-related potentialsWorking memoryZolpidem
Type
Short communication
Information
European Psychiatry , Volume 21 , Issue 2 , March 2006 , pp. 135 - 137
Copyright
Copyright © Elsevier SAS 2006

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