Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-15T23:21:34.378Z Has data issue: false hasContentIssue false

Impulsividad en el trastorno bipolar-II: ¿rasgo, estado o ambos?

Published online by Cambridge University Press:  12 May 2020

Franco Benazzi*
Affiliation:
Universidad de California en San Diego, CA, Centro de Investigación de Psiquiatría de Forli, Italia Departamento de Psiquiatría, Universidad de Szeged, Szeged, Hungría Departamento de Psiquiatría, Servicio Médico Nacional, Forli, Italia
Get access

Resumen

Antecedentes.

En el trastorno bipolar-II (BP-II), la impulsividad (definida en el DSM-IV-TR como desarrollo de actividades con riesgo excesivo) es uno de los síntomas la hipomanía, pero no está claro si la impulsividad es también un rasgo del BP-II.

Objetivo.

Determinar si la impulsividad es también un rasgo del BP-II.

Métodos.

Ciento treinta y seis pacientes ambulatorios con BP-II derivados consecutivamente (evaluados por depresión en la presentación por un psiquiatra especializado en trastornos del ánimo con la Entrevista Clínica Estructurada para DSM-IV), con autoevaluación del rasgo de impulsividad durante el seguimiento, usando el Cuestionario de Personalidad de la Entrevista Clínica Estructurada para los Trastornos del Eje II del DSM-IV, en una consulta privada. Los rasgos de cambios bruscos del estado de ánimo también fueron autoevaluados, usando el TEMPS-A. La naturaleza del rasgo de impulsividad en el BP-II podría confirmarse si se encontraba (1) una frecuencia relativamente alta, (2) una asociación entre el rasgo de impulsividad y los síntomas de hipomanía pasada, sobre todo, impulsividad, (3) una relación dosis-respuesta entre el número de síntomas de hipomanía pasados y el rasgo de impulsividad, y (4) una asociación entre el rasgo de impulsividad y los rasgos de cambios bruscos del estado de ánimo (un rasgo típico del BP-II).

Resultados.

Sencontró el rasgo de impulsividad en el 41,1% de los pacientes con BP-II. Comparados con los pacientes con BP-II sin impulsividad, entre los pacientes con BP-II con impulsividad había significativamente más hombres, más rasgos de cambios bruscos del estado de ánimo, más síntomas de hipomanía pasados (ánimo irritable, locuacidad, aumento de actividad para conseguir un objetivo) y actividades con riesgo excesivo (es decir, estado de impulsividad), que correspondió a una sobreactividad de riesgo irritable. El estado de impulsividad pasado y el rasgo de impulsividad se asociaron significativamente. El número de síntomas de hipomanía pasados y el rasgo de impulsividad se correlacionaron significativamente. Se encontró una relación dosis-respuesta entre el número de síntomas de hipomanía pasados y el rasgo de impulsividad.

Discusión.

Los resultados sugieren que el rasgo de impulsividad puede ser una característica del BP-II. Debería tenerse en cuenta la limitación de la autoevaluación de los rasgos de personalidad. Estos resultados pueden tener un impacto importante sobre el tratamiento, ya que la combinación de rasgo de impulsividad y cambios bruscos del estado de ánimo puede facilitar las recaídas y los estados mixtos, que los estabilizantes del ánimo podrían prevenir/retardar.

Type
Artículo original
Copyright
Copyright © European Psychiatric Association 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bibliografía

Akiskal, HS, Maser, JD, Zeller, PJ, Endicott, J, Coryell, W, Keller, M, et al. Switching from ‘unipolar’ to bipolar II. An 11-year prospective study of clinical and temperamental predictors in 559 patients. Arch Gen Psychiatry 1995;52:114–23.CrossRefGoogle ScholarPubMed
Akiskal, HS. The prevalent clinical spectrum of bipolar disorders: beyond DSM-1V. J Clin Psychopharmacol 1996; 16(2 Suppl. 1):4S14.CrossRefGoogle Scholar
Akiskal, HS, Hantouche, EG, Bourgeois, ML, Azorin, JM, Sechter, D, Allilaire, JF, et al. Gender, temperament, and the clinical picture in dysphoric mixed mania: findings from a French national study (EPIMAN). J Affect Disord 1998;50:175–86.CrossRefGoogle Scholar
Akiskal, HS, Benazzi, F. Family history validation of the bipolar nature of depressive mixed states. J Affect Disord 2003;73:113–22.CrossRefGoogle ScholarPubMed
Akiskal, HS. Demystifying borderline personality: critique of the concept and unorthodox reflections on its natural kinship with the bipolar spectrum. Acta Psychiatr Scand 2004;110:401–7.Google ScholarPubMed
Akiskal, HS, Benazzi, F. Optimizing the detection of bipolar II disorder in outpatient private practice: toward a systematization of clinical diagnostic wisdom. J Clin Psychiatry 2005;66:914–21.CrossRefGoogle Scholar
Akiskal, HS, Akiskal, KK, Haykal, RF, Manning, JS, Connor, PD. TEMPSA: progress towards validation of a self-rated clinical of the temperament evaluation of the Memphis, Pisa, Paris and San Diego autoquestionnaire. J Affect Disord 2005;85:316.CrossRefGoogle Scholar
Akiskal, HS, Akiskal, KK, Lancrenon, S, Hantouche, EG, Fraud, JP, Gury, C, et al. Validating the bipolar spectrum in the French National EPIDEP Study: overview of the phenomenology and relative prevalence of its clinical prototypes. J Affect Disord 2006;96:197205.CrossRefGoogle ScholarPubMed
Akiskal, HS, Kilzieh, N, Maser, JD, Clayton, PJ, Schettler, PJ, Traci, Shea M, et al. The distinct temperament profiles of bipolar I, bipolar II and unipolar patients. J Affect Disord 2006;92:1933.CrossRefGoogle ScholarPubMed
Akiskal, HS, Akiskal, KK, Lancrenon, S, Hantouche, E. Validating the soft bipolar spectrum in the French National EPIDEP Study: the prominence of BP-II 1/2. J Affect Disord 2006;96:207–13.CrossRefGoogle ScholarPubMed
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed., text revision (DSM-IV-TR). Washington, DC: American Psychiatric Association; 2000.Google Scholar
Angst, J, Gamma, A, Benazzi, F, Ajdacic, V, Eich, D, Rossler, W. Toward a re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania. J Affect Disord 2003;73:133–46.CrossRefGoogle Scholar
Angst, J, Adolfsson, R, Benazzi, F, Gamma, A, Hantouche, E, Meyer, TD, et al. The HCL-32: towards a self-assessment tool for hypomanic symptoms in outpatients. J Affect Disord 2005;88:217–33.CrossRefGoogle ScholarPubMed
Baldessarini, RJ, Tondo, L, Davis, P, Pompili, M, Goodwin, FK, Hennen, J. Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review. Bipolar Disord 2006;8:625–39.CrossRefGoogle ScholarPubMed
Benazzi, F. Borderline personality disorder and bipolar II disorder in private practice depressed outpatients. Compr Psychiatry 2000;41:106–10.CrossRefGoogle ScholarPubMed
Benazzi, F. Depression with racing thoughts. Psychiatry Res 2003;120:273–82.CrossRefGoogle ScholarPubMed
Benazzi, F. Diagnosis of bipolar II disorder: a comparison of structured versus semistructured interviews. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:985–91.CrossRefGoogle ScholarPubMed
Benazzi, F. Validating Angst's “ups & downs” personality trait as a new marker of bipolar II disorder. Eur Arch Psychiatry Clin Neurosci 2004;254:4854.CrossRefGoogle ScholarPubMed
Benazzi, F. Family history validation of a definition of mixed depression. Compr Psychiatry 2005;46:159–66.CrossRefGoogle ScholarPubMed
Benazzi, F. Agitated depression in bipolar II disorder. World J Biol Psychiatry 2005;6:198205.CrossRefGoogle ScholarPubMed
Benazzi, F. The continuum/spectrum concept of mood disorders: is mixed depression the basic link?. Eur Arch Psychiatry Clin Neurosci 2006;256:512–5.CrossRefGoogle ScholarPubMed
Benazzi, F. Gender differences in bipolar-II disorder. Eur Arch Psychiatry Clin Neurosci 2006;256:6771.CrossRefGoogle ScholarPubMed
Benazzi, F. Mixed depression, suicidality, and antidepressants. J Clin Psychiatry 2006;67:1650–1.CrossRefGoogle ScholarPubMed
Benazzi, F. Antidepressant-induced or clinician-induced suicidality in depression?. Am J Psychiatry 2006;163:1644.CrossRefGoogle ScholarPubMed
Benazzi, F. Impact of temperamental mood labil ity on depressive mixed State. Psychopathology 2006;39:1924.CrossRefGoogle Scholar
Benazzi, F. Borderline personality—bipolar spectrum relationship. Prog Neuropsychopharmacol Biol Psychiatry 2006;30:6874.CrossRefGoogle ScholarPubMed
Benazzi, F. Is overactivity the care feature of hypomania in bipolar II disorder?. Psychopathology 2007;40:5460.CrossRefGoogle Scholar
Benazzi, F. Is there a continuity between bipoiar and depressive disorders?. Psychother Psychosom 2007;76:70–6.CrossRefGoogle Scholar
Benazzi, F. Bipolar disorder—focus on bipolar II disorder and mixed depression. Lancet 2007;369:935–45.CrossRefGoogle ScholarPubMed
Benazzi, F, Akiskal, HS. Refining the evaluation of bipolar II: beyond the strict SCID-CV guidelines for hypomania. J Affect Disord 2003;73:33–8.CrossRefGoogle ScholarPubMed
Benazzi, F, Akiskal, HS. A downscaled practical measure of mood lability as a scrcening tool for bipolar II. J Affect Disord 2005;84:225–32.CrossRefGoogle ScholarPubMed
Benazzi, F, Akiskal, HS. The duration of hypomania in bipolar-II disorder in private practice: methodology and validation. J Affect Disord 2006;96:189–96.CrossRefGoogle Scholar
Blechert, J, Meyer, TD. Are measures o f hypomanic personality, impulsive nonconformity and rigidity predictors of bipolar symptoms?. Br J Clin Psychol 2005;44:1527.CrossRefGoogle Scholar
Chapman, LJ, Chapman, JP, Numbers, JS, Edell, WS, Carpenter, BN, Beckfield, D. Impulsive nonconformity as a trait contributing to the prediction of psychotic-like and schizotypal symptoms. J Nerv Ment Dis 1984;172:681–91.CrossRefGoogle ScholarPubMed
Christodoulou, T, Lewis, M, Ploubidis, GB, Frangou, S. The relationship of impulsivity to response inhibition and decision-making in remitted patients with bipolar disorder. Eur Psychiatry 2006;21:270-3.CrossRefGoogle ScholarPubMed
Cloninger, CR. A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry 1987;44:573–88.CrossRefGoogle ScholarPubMed
Dunner, DL, Tay, KL. Diagnostic reliability of the history of hypomania in bipolar II patients and patients with major depression. Compr Psychiatry 1993;34:303–7.CrossRefGoogle ScholarPubMed
Erdman, HP, Klein, MH, Greist, JH, Bass, SM, Bires, JK, Machtinger, PE. A comparison of the Diagnostic Interview Schedule and clinical diagnosis. Am J Psychiatry 1987;144:1477–80.Google ScholarPubMed
Fergus, EL, Miller, RB, Luckenbaugh, DA, Leverich, GS, Findling, RL, Speer, AM, et al. Is there progression from irritability/dyscontrol to major depressive and manic symptoms? A retrospective community survey of parents of bipolar children. J Affect Disord 2003;77:71–8.CrossRefGoogle ScholarPubMed
First, MB, Spitzer, RL, Gibbon, M, Williams, JBW. Structured clinical interview for DSM-IV axis I disorders-clinician version (SCID-CV). Washington, DC: American Psychiatric Press; 1997.Google Scholar
First, MB, Gibbon, M, Spitzer, RL, Williams, JBW, Benjamin, LS. SCID-II Personality questionnaire. Washington, DC: American Psychiatric Press; 1997.Google Scholar
Gunderson, J, Zanarini, MC, Kisiel, CL. Borderline personality disorder. In: Widiger, TA, Frances, AJ, Pincus, HL, Ross, R, First, MB, Davis, WW, editors. DSM-IV sourcebook, vol. 2. Washington, DC: American Psychiatric Association; 1996. p. 717-31.Google Scholar
Gunderson, JG, Weinberg, I, Daversa, MT, Kueppenbender, KD, Zanarini, MC, Shea, MT, et al. Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder. Am J Psychiatry 2006;163:1173–8.CrossRefGoogle ScholarPubMed
Hantouche, EG, Akiskal, HS. Toward a defmition of a cyclothymic behavioral endophenotype: which traits tap the familial diathesis for bipolar II disorder?. J Affect Disord 2006;96:233–7.CrossRefGoogle Scholar
Henry, C, Mitropoulou, V, New, AS, Koenigsberg, HW, Silverman, J, Siever, LJ. Affective instability and impulsivity in borderline personality and bipolar II disorders: similarities and differences. J Psychiatr Res 2001;35:307–12.CrossRefGoogle ScholarPubMed
Kessler, RC, Akiskal, HS, Angst, J, Guyer, M, Hirschfeld, RM, Menkangas, KR, et al. Validity of the assessment of bipolar spectrum disorders in the WHO CIDI 3.0. J Affect Disord 2006;69:259–69.CrossRefGoogle Scholar
Koukopoulos, A, Albert, MJ, Sani, G, Koukopoulos, AE, Girardi, P. Mixed depressive states: nosologic and therapeutic issues. Int Rev Psychiatry 2005;17:2137.CrossRefGoogle ScholarPubMed
Kraepelin, E. Manic-depressive insanity and paranoia. Edinburgh: Livingstone E&S; 1921.CrossRefGoogle Scholar
Kwapil, TR, Miller, MB, Zinser, MC, Chapman, LJ, Chapman, J, Eckblad, M. A longitudinal study of high scorers on the hypomanic personality scale. J Abnorm Psychol 2000;109:222–6.CrossRefGoogle ScholarPubMed
Lara, DR, Pinto, O, Akiskal, K, Akiskal, HS. Toward an integrative model of the spectrum of mood, behavioral and personality disorders based on fear and anger traits: I. Clinical implications. J Affect Disord 2006;94:6787.CrossRefGoogle ScholarPubMed
Links, PS, Heslegrave, R, van Reekum, R. Impulsivity: core aspect of borderline personality disorder. J Personal Disord 1999;13:19.CrossRefGoogle ScholarPubMed
McGirr, A, Seguin, M, Renaud, J, Benkelfat, C, Alda, M, Turecki, G. Gender and risk factors for suicide: evidence for heterogeneity in predisposing mechanisms in a psychological autopsy study. J Clin Psychiatry 2006;67:1612–7.CrossRefGoogle Scholar
Paris, J. Borderline or bipolar? Distinguishing borderline personality disorder from bipolar spectrum disorders. Harv Rev Psychiatry 2004;12:140–5.CrossRefGoogle ScholarPubMed
Patton, JH, Stanford, MS, Barratt, ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol 1995;51:768–74.3.0.CO;2-1>CrossRefGoogle ScholarPubMed
Perugi, G, Toni, C, Travierso, MC, Akiskal, HS. The role of cyclothymia in atypical depression: toward a data-based reconceptualization o f the borderline—bipolar II connection. J Affect Disord 2003;73:8798.CrossRefGoogle Scholar
Sato, T, Bottlender, R, Schroter, A, Moller, H-J. Frequency of manic symptoms during a depressive episode and unipolar ‘depressive mixed State’ as bipolar spectrum. Acta Psychiatr Scand 2003;107:268–74.CrossRefGoogle ScholarPubMed
Scott, J, Pope, M. Cognitive styles in individuais with bipolar disorders. Psychol Med 2003;33:1081–8.CrossRefGoogle Scholar
Simpson, SG, McMahon, FJ, Mclnnis, MG, MacKinnon, DF, Edwin, D, Folstein, SE, et al. Diagnostic reliability of bipolar II diagnosis. Arch Gen Psychiatry 2002;59:736–40.CrossRefGoogle Scholar
Soloff, PH, Kelly, TM, Strotmeyer, SJ, Malone, KM, Mann, JJ. Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder. Psychiatry Res 2003;119:1124.CrossRefGoogle ScholarPubMed
Solomon, DA, Shea, MT, Leon, AC, Mueller, TI, Coryell, W, Maser, JD, et al. Personality traits in subjects with bipolar I disorder in remission. J Affect Disord 1996;40:41–8.CrossRefGoogle ScholarPubMed
Smith, DJ, Muir, WJ, Blackwood, DH. Is borderline personality disorder part of the bipolar spectrum?. Harv Rev Psychiatry 2004; 12:133–9.CrossRefGoogle ScholarPubMed
Stata 8 User's Guide. College station. Texas, USA: Stata Press; 2003.Google Scholar
Stone, MH. Relationship of borderline personality disorder and bipolar disorder. Am J Psychiatry 2006;163:1126–8.CrossRefGoogle ScholarPubMed
Swann, AC, Anderson, JC, Dougherty, DM, Moeller, FG. Measurement of inter-episode impulsivity in bipolar disorder. Psychiatry Res 2001;101:195–7.CrossRefGoogle ScholarPubMed
Swann, AC, Pazzaglia, P, Nicholls, A, Dougherty, DM, Moeller, FG. Impulsivity and phase o f illness in bipolar disorder. J Affect Disord 2003;73:105–11.CrossRefGoogle Scholar
Tondo, L, Baldessarini, RJ, Hennen, J, Floris, G. Lithium maintenance treatment of depression and mania in bipolar I and bipolar II disorders. Am J Psychiatry 1998;155:638–45.CrossRefGoogle ScholarPubMed
Van Praag, HM. Anxiety/aggression-driven depression. A paradigm of functionalization and verticalization of psychiatric diagnosis. Prog Neuropsychopharmacol Biol Psychiatry 2001;25:893924.CrossRefGoogle ScholarPubMed