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Citalopram en pacientes retrasados mentales con depresión: una investigation clínica a largo plazo

Published online by Cambridge University Press:  12 May 2020

W. M. A. Verhoeven ,
M. J. Veendrik-Meekes ,
G. A. J. Jacobs ,
Y. W. M. M. van den Berg  and
S. Tuinier
W. M. A. Verhoeven
Affiliation:
Instituto Vincent van Gogh para la Psiquiatría, Stationsweg 46, 5803AC Venray, Países Bajos Universidad Erasmo, Facultad de Medicina y Ciencias Médicas, Rotterdam, Países Bajos
M. J. Veendrik-Meekes
Affiliation:
Instituto para la Epilepsia Kempenhaeghe, Heeze, Países Bajos
G. A. J. Jacobs
Affiliation:
Instituto para el Retraso Mental “Saamvliet”, Gennep, Países Bajos
Y. W. M. M. van den Berg
Affiliation:
Instituto Vincent van Gogh para la Psiquiatría, Stationsweg 46, 5803AC Venray, Países Bajos
S. Tuinier
Affiliation:
Instituto Vincent van Gogh para la Psiquiatría, Stationsweg 46, 5803AC Venray, Países Bajos
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Resumen

Se investigó el efecto del citalopram en 20 pacientes retrasados mentales que padecían de un trastorno depresivo caracterizado por alteraciones en los dominios de la afectividad, la motivatión, la acti-vidad motora y los signos vitales. El estudio siguió un diseño abierto controlado en la línea de base. Se inició el citalopram en una dosis diaria de 20 mg que se mantuvo igual durante 6 semanas. Después, la dosis se ajustó hasta un maximo de 60 mg por día. Los efectos del tratamiento se evaluaron según la Escala de Mejoría Clinica Global (CGIS) después de al menos 6 meses. En 12 de los 20 pacientes se observó una mejoría de moderada a acusada en todos los dominios en el tratamiento con 20-40 mg de citalopram diarios. El tratamiento durante un afio en la dosis efectiva prevenía la recaída de los sfntomas depresivos. El uso de anticonvulsivantes sedantes redujo la sensibilidad al tratamiento. No se observaron interacciones. Se concluye que el citalopram es un antidepresivo bien tolerado, seguro y efectivo en sujetos retrasados mentales con trastornos depresivos.

Keywords

citalopramdepresioninteraccionesretraso mentalcomportamiento autolesivoestereotipias
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 8 , Issue 4 , May 2001 , pp. 242 - 247
Copyright
Copyright © European Psychiatric Association 2001

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