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A massive intrathecal cefazoline overdose

Published online by Cambridge University Press:  16 August 2006

E. W. Lang ,
D. Weinert ,
A. Behnke ,
K. Pflug-Rolfes  and
M. Rautenberg
E. W. Lang
Affiliation:
Department of Neurological Surgery, Christian Albrechts Universität, Weimarer Strasse 8, D-24106 Kiel, Germany
D. Weinert
Affiliation:
Department of Neurological Surgery, Christian Albrechts Universität, Weimarer Strasse 8, D-24106 Kiel, Germany
A. Behnke
Affiliation:
Department of Neurological Surgery, Christian Albrechts Universität, Weimarer Strasse 8, D-24106 Kiel, Germany
K. Pflug-Rolfes
Affiliation:
Department of Microbiology, Christian Albrechts Universität, Weimarer Strasse 8, D-24106 Kiel, Germany
M. Rautenberg
Affiliation:
Department of Neurological Surgery, Christian Albrechts Universität, Weimarer Strasse 8, D-24106 Kiel, Germany
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Abstract

This case report describes the clinical course of a patient who inadvertently received a massive intrathecal cefazoline overdose through a lumbar drain, which had been placed after trans-sphenoidal surgery for a pituitary adenoma. She received high-dose barbiturate therapy and was monitored with electroencephalography (EEG), somatosensory evoked potentials (SSEP), brainstem auditory evoked potentials (BAEP) and transcranial Doppler ultrasound (TCD). No cerebrospinal fluid (CSF) exchange was performed, but CSF was drained continuously with daily CSF-cefazoline level monitoring. Despite the extremely toxic dose, the patient soon recovered completely.

Keywords

cephalosporineintrathecal administrationoverdoseneurotoxicity
Type
Case Report
Information
European Journal of Anaesthesiology , Volume 16 , Issue 3 , March 1999 , pp. 204 - 205
Copyright
1999 European Society of Anaesthesiology

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