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Haemodynamic and splanchnic organ blood flow responses during sevoflurane-induced hypotension in dogs

Published online by Cambridge University Press:  16 August 2006

S. Takeda ,
N. Sato  and
T. Tomaru
S. Takeda
Affiliation:
Showa University Fujigaoka Hospital, Department of Anesthesiology, Yokohama, Japan
N. Sato
Affiliation:
Showa University Fujigaoka Hospital, Department of Anesthesiology, Yokohama, Japan
T. Tomaru
Affiliation:
Showa University Fujigaoka Hospital, Department of Anesthesiology, Yokohama, Japan
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Abstract

Background and objective: The safety of hypotension induced by sevoflurane and splanchnic organ blood flow remains to be clarified. The aim was to investigate the effects of sevoflurane-induced hypotension on systemic haemodynamics and splanchnic organ blood flows in dogs.

Methods: Mean arterial pressure was maintained at 60 mmHg by increasing sevoflurane concentrations. The renal, hepatic and pancreatic blood flows were measured by using the hydrogen clearance method.

Results: Hypotension induced by sevoflurane resulted in a 50% decrease of mean arterial pressure due to a 30% reduction in systemic vascular resistance associated with a 30% decrease in cardiac index. The mechanisms causing the lower cardiac index were produced by the decreases in heart rate and left ventricular dP/dtmax. Renal, hepatic and pancreatic blood flow were reduced, but the whole-body oxygen consumption did not change during the hypotensive period.

Conclusions: The haemodynamic changes induced by sevoflurane were caused by the suppression of arterial baroreflexes and myocardial depression, but splanchnic organ blood flows, though reduced, could provide adequate peripheral perfusion to meet the decrease in oxygen supply.

Keywords

anaesthetic techniqueshypotensioninducedanaestheticsvolatilesevofluranehaemodynamicsregional blood flowkidneyliverpancreas
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 19 , Issue 6 , June 2002 , pp. 442 - 446
Copyright
2002 European Society of Anaesthesiology

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